The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic Review
Infections following treatment of rheumatic diseases are common and potentially life threatening. Severe infections may be related to the overall susceptibility in rheumatic diseases, neutropenia in connective tissue diseases, as well as secondary hypogammaglobulinemia (SHG) due to the use of immuno...
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| Language: | English |
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World Scientific Publishing
2024-12-01
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| Series: | Journal of Clinical Rheumatology and Immunology |
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| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661341724300027 |
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| author | Winnie Wan Yin Yeung |
| author_facet | Winnie Wan Yin Yeung |
| author_sort | Winnie Wan Yin Yeung |
| collection | DOAJ |
| description | Infections following treatment of rheumatic diseases are common and potentially life threatening. Severe infections may be related to the overall susceptibility in rheumatic diseases, neutropenia in connective tissue diseases, as well as secondary hypogammaglobulinemia (SHG) due to the use of immunosuppressants. Herein, a case of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with recurrent cytomegalovirus (CMV) infections and SHG was described, followed by discussion of pathophysiology, clinical presentation, risk factors, and management of SHG, emphasizing the importance of baseline immunoglobulin level monitoring. |
| format | Article |
| id | doaj-art-72dd52c078b7453493a723d339f5941a |
| institution | Kabale University |
| issn | 2661-3417 2661-3425 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Clinical Rheumatology and Immunology |
| spelling | doaj-art-72dd52c078b7453493a723d339f5941a2025-02-05T07:39:34ZengWorld Scientific PublishingJournal of Clinical Rheumatology and Immunology2661-34172661-34252024-12-012402848910.1142/S2661341724300027The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic ReviewWinnie Wan Yin Yeung0The University of Hong Kong, Hong Kong SAR, ChinaInfections following treatment of rheumatic diseases are common and potentially life threatening. Severe infections may be related to the overall susceptibility in rheumatic diseases, neutropenia in connective tissue diseases, as well as secondary hypogammaglobulinemia (SHG) due to the use of immunosuppressants. Herein, a case of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with recurrent cytomegalovirus (CMV) infections and SHG was described, followed by discussion of pathophysiology, clinical presentation, risk factors, and management of SHG, emphasizing the importance of baseline immunoglobulin level monitoring.https://www.worldscientific.com/doi/10.1142/S2661341724300027Secondary HypogammaglobulinemiaImmunosuppressionImmunosuppressive MedicationsAutoimmune Rheumatic DiseasesB-cell Targeting Therapy |
| spellingShingle | Winnie Wan Yin Yeung The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic Review Journal of Clinical Rheumatology and Immunology Secondary Hypogammaglobulinemia Immunosuppression Immunosuppressive Medications Autoimmune Rheumatic Diseases B-cell Targeting Therapy |
| title | The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic Review |
| title_full | The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic Review |
| title_fullStr | The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic Review |
| title_full_unstemmed | The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic Review |
| title_short | The Importance of Monitoring Baseline and Regular Immunoglobulin Levels in Managing Secondary Hypogammaglobulinemia in Rheumatic Diseases: A Case Report and Systematic Review |
| title_sort | importance of monitoring baseline and regular immunoglobulin levels in managing secondary hypogammaglobulinemia in rheumatic diseases a case report and systematic review |
| topic | Secondary Hypogammaglobulinemia Immunosuppression Immunosuppressive Medications Autoimmune Rheumatic Diseases B-cell Targeting Therapy |
| url | https://www.worldscientific.com/doi/10.1142/S2661341724300027 |
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