Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study
Background. Previous studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet long-term follow-up studies to elucidate this association are lacking. We aimed to identify the relationship between NAFLD and H. pylori in these peo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6696473 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551955927400448 |
|---|---|
| author | Xia-Xia Zhao Rui-Ling Wang Ming-Hao Liu Xiao-jun Huang |
| author_facet | Xia-Xia Zhao Rui-Ling Wang Ming-Hao Liu Xiao-jun Huang |
| author_sort | Xia-Xia Zhao |
| collection | DOAJ |
| description | Background. Previous studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet long-term follow-up studies to elucidate this association are lacking. We aimed to identify the relationship between NAFLD and H. pylori in these people. Methods. A total of 2,934 adults between June 2013 and October 2017 were collected; among them, 675 people met the requirements. People were assessed for H. pylori infection diagnosis as detected by the carbon-13 urea breath test; they were also assessed for NAFLD diagnosis by ultrasound. Results. H. pylori infection was present in 206 patients (30.5%), and 469 (69.5%) participants were classified as controls. Participants with H. pylori infection had a higher rate of incident NAFLD than those who were uninfected (37/206; 18% versus 73/469; 15.6%) (p<0.001). Compared with the control group, the recovery rate of NAFLD in the H. pylori+ve group was low (6/206, 2.9% versus 33/469, 7.0%) (p<0.001). Besides, the incidence of uric acid, postprandial blood glucose, TG, LDL-C, HDL-C, and fasting plasma glucose was significantly different between the two groups (p<0.001), but no difference was found in alanine aminotransferase (ALT), liver-total protein, urea nitrogen, and cholesterol (p>0.05). Conclusion. H. pylori infection was a risk factor for NAFLD and affected the occurrence or reversal of NAFLD, indicating that H. pylori infection eradication might play a role in reducing the risk of NAFLD. |
| format | Article |
| id | doaj-art-72dab312379d4bb5bf8b74d744a1dc7e |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-72dab312379d4bb5bf8b74d744a1dc7e2025-02-03T06:00:00ZengWileyGastroenterology Research and Practice1687-630X2021-01-01202110.1155/2021/6696473Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort StudyXia-Xia Zhao0Rui-Ling Wang1Ming-Hao Liu2Xiao-jun Huang3Department of GastroenterologyThe PLA Rocket Force Characteristic Medical CenterThe PLA Rocket Force Characteristic Medical CenterDepartment of GastroenterologyBackground. Previous studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet long-term follow-up studies to elucidate this association are lacking. We aimed to identify the relationship between NAFLD and H. pylori in these people. Methods. A total of 2,934 adults between June 2013 and October 2017 were collected; among them, 675 people met the requirements. People were assessed for H. pylori infection diagnosis as detected by the carbon-13 urea breath test; they were also assessed for NAFLD diagnosis by ultrasound. Results. H. pylori infection was present in 206 patients (30.5%), and 469 (69.5%) participants were classified as controls. Participants with H. pylori infection had a higher rate of incident NAFLD than those who were uninfected (37/206; 18% versus 73/469; 15.6%) (p<0.001). Compared with the control group, the recovery rate of NAFLD in the H. pylori+ve group was low (6/206, 2.9% versus 33/469, 7.0%) (p<0.001). Besides, the incidence of uric acid, postprandial blood glucose, TG, LDL-C, HDL-C, and fasting plasma glucose was significantly different between the two groups (p<0.001), but no difference was found in alanine aminotransferase (ALT), liver-total protein, urea nitrogen, and cholesterol (p>0.05). Conclusion. H. pylori infection was a risk factor for NAFLD and affected the occurrence or reversal of NAFLD, indicating that H. pylori infection eradication might play a role in reducing the risk of NAFLD.http://dx.doi.org/10.1155/2021/6696473 |
| spellingShingle | Xia-Xia Zhao Rui-Ling Wang Ming-Hao Liu Xiao-jun Huang Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study Gastroenterology Research and Practice |
| title | Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study |
| title_full | Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study |
| title_fullStr | Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study |
| title_full_unstemmed | Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study |
| title_short | Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study |
| title_sort | is the occurrence or reversal of nonalcoholic fatty liver disease associated with long term helicobacter pylori infection among chinese adults a cohort study |
| url | http://dx.doi.org/10.1155/2021/6696473 |
| work_keys_str_mv | AT xiaxiazhao istheoccurrenceorreversalofnonalcoholicfattyliverdiseaseassociatedwithlongtermhelicobacterpyloriinfectionamongchineseadultsacohortstudy AT ruilingwang istheoccurrenceorreversalofnonalcoholicfattyliverdiseaseassociatedwithlongtermhelicobacterpyloriinfectionamongchineseadultsacohortstudy AT minghaoliu istheoccurrenceorreversalofnonalcoholicfattyliverdiseaseassociatedwithlongtermhelicobacterpyloriinfectionamongchineseadultsacohortstudy AT xiaojunhuang istheoccurrenceorreversalofnonalcoholicfattyliverdiseaseassociatedwithlongtermhelicobacterpyloriinfectionamongchineseadultsacohortstudy |