Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells

Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells

Abstract Background In acute kidney injury (AKI), inflammatory crosstalk between tubular epithelial cells (TECs) and immune cells drives disease progression. Although the Axl-SOCS3 axis in myeloid cells typically suppresses inflammation, TEC-specific SOCS3 deletion paradoxically protects against AKI...

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Bibliographic Details
Main Authors: Xin Kang, Qiuhua Gu, Xi Cheng, Junya Jia, Tiekun Yan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Nephrology
Subjects:
Acute kidney injury
Inflammation
Tubular epithelial cells
Axl
Suppressor of cytokine signaling 3
Online Access:https://doi.org/10.1186/s12882-025-04222-z
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