Chemical cross‐linking facilitates antigen uptake and presentation and provides improved protection from Mpox with a dual‐antigen subunit vaccine

Chemical cross‐linking facilitates antigen uptake and presentation and provides improved protection from Mpox with a dual‐antigen subunit vaccine

Abstract Antigen uptake, processing, and presentation are crucial for the immune responses of protein‐based vaccines. Herein, we introduced a reversible chemical cross‐linking strategy to engineer protein antigens, which can be tracelessly removed upon antigen‐presenting cell (APC) uptake and cellul...

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Main Authors: Long Chen, Chao Shang, Zihao Wang, Mengzhu Zheng, Cuiling Zhang, Dapeng Li, Zhanqun Yang, Yuchao Dong, Yuru Xu, Yunsheng Yuan, Shiyong Fan, Wu Zhong, Jian Lin, Xiao Li
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:MedComm
Subjects:
antigen uptake and presentation
chemical cross‐linking
dual‐antigen
monkeypox virus
subunit vaccine
Online Access:https://doi.org/10.1002/mco2.70045
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https://doi.org/10.1002/mco2.70045

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