Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis

Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis

Surgery-induced microglial activation is critical in mediating postoperative cognitive dysfunction (POCD) in elderly patients, where the important protective effect of dexmedetomidine has been indicated. However, the mechanisms of action of dexmedetomidine during the neuroinflammatory response that...

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Bibliographic Details
Main Authors: Zhichao Wu, Han Wang, Zuan Shi, Yalan Li
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2022/1353778
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