Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population
Background. Vitamin D (25(OH)D) deficiency is a prevalent condition worldwide. However, the highest prevalence rates of 25(OH)D deficiency have been attributed to regions with higher latitude. A close association between 25(OH)D and cardio-cerebrovascular (CCV) risk factors and major health problems...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2021/5550222 |
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| author | Rocco Capuano Federica Marchese Raffaella Sica Eduardo Capuano Marzia Manilia Anna Grazia Iannone Alessandro D’Ambrosio Alvino Bisecco Gioacchino Tedeschi Antonio Gallo Vincenzo Capuano |
| author_facet | Rocco Capuano Federica Marchese Raffaella Sica Eduardo Capuano Marzia Manilia Anna Grazia Iannone Alessandro D’Ambrosio Alvino Bisecco Gioacchino Tedeschi Antonio Gallo Vincenzo Capuano |
| author_sort | Rocco Capuano |
| collection | DOAJ |
| description | Background. Vitamin D (25(OH)D) deficiency is a prevalent condition worldwide. However, the highest prevalence rates of 25(OH)D deficiency have been attributed to regions with higher latitude. A close association between 25(OH)D and cardio-cerebrovascular (CCV) risk factors and major health problems has been identified. Aim. To establish the prevalence of 25(OH)D deficiency and to investigate the relationship between 25(OH)D levels and CCV risk factors (blood cholesterol, triglycerides, glucose concentrations, body mass index, and systolic and diastolic blood pressure) in a cohort representative of Southern Italy. Methods. The prevalence of 25(OH)D levels was evaluated in 1200 subjects aged 25–74 years (600 males and 600 females), enrolled in the “VIP” (from Italian for Irno Valley Prevention) Project, whereas multiple linear regression analysis was used to determine the relationship between 25(OH)D levels and CCV risk factors. Results. Only 13.3% of females and 11.1% of males showed adequate serum concentrations of 25(OH)D (≥30 ng/ml), while 59.3% of females and 55.1% of males showed 25(OH)D deficient levels (<20 ng/ml). We observed an independent association between 25(OH)D concentrations and metabolic syndrome score, LDL cholesterol, HDL cholesterol, and corrected QT (cQT). Conclusions. We report a high prevalence of 25(OH)D deficiency across the largest Italian adult population studied so far and, in particular, the first across Southern Italy; furthermore, we provide data on the association between 25(OH)D deficiency and higher CCV risk factors. |
| format | Article |
| id | doaj-art-72cb1dd019554ea69569cb11c28ceff0 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-72cb1dd019554ea69569cb11c28ceff02025-02-03T01:13:07ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322021-01-01202110.1155/2021/55502225550222Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian PopulationRocco Capuano0Federica Marchese1Raffaella Sica2Eduardo Capuano3Marzia Manilia4Anna Grazia Iannone5Alessandro D’Ambrosio6Alvino Bisecco7Gioacchino Tedeschi8Antonio Gallo9Vincenzo Capuano10Cardiology Unit “G. Fucito” Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, ItalyCardiology Unit “G. Fucito” Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, ItalyCardiology Unit “G. Fucito” Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, ItalyCardiology Unit “G. Fucito” Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, ItalyCardiology Unit “G. Fucito” Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, ItalyCardiology Unit “G. Fucito” Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Napoli, ItalyCardiology Unit “G. Fucito” Hospital,Mercato San Severino, Azienda Ospedaliera Universitaria di Salerno, Salerno, ItalyBackground. Vitamin D (25(OH)D) deficiency is a prevalent condition worldwide. However, the highest prevalence rates of 25(OH)D deficiency have been attributed to regions with higher latitude. A close association between 25(OH)D and cardio-cerebrovascular (CCV) risk factors and major health problems has been identified. Aim. To establish the prevalence of 25(OH)D deficiency and to investigate the relationship between 25(OH)D levels and CCV risk factors (blood cholesterol, triglycerides, glucose concentrations, body mass index, and systolic and diastolic blood pressure) in a cohort representative of Southern Italy. Methods. The prevalence of 25(OH)D levels was evaluated in 1200 subjects aged 25–74 years (600 males and 600 females), enrolled in the “VIP” (from Italian for Irno Valley Prevention) Project, whereas multiple linear regression analysis was used to determine the relationship between 25(OH)D levels and CCV risk factors. Results. Only 13.3% of females and 11.1% of males showed adequate serum concentrations of 25(OH)D (≥30 ng/ml), while 59.3% of females and 55.1% of males showed 25(OH)D deficient levels (<20 ng/ml). We observed an independent association between 25(OH)D concentrations and metabolic syndrome score, LDL cholesterol, HDL cholesterol, and corrected QT (cQT). Conclusions. We report a high prevalence of 25(OH)D deficiency across the largest Italian adult population studied so far and, in particular, the first across Southern Italy; furthermore, we provide data on the association between 25(OH)D deficiency and higher CCV risk factors.http://dx.doi.org/10.1155/2021/5550222 |
| spellingShingle | Rocco Capuano Federica Marchese Raffaella Sica Eduardo Capuano Marzia Manilia Anna Grazia Iannone Alessandro D’Ambrosio Alvino Bisecco Gioacchino Tedeschi Antonio Gallo Vincenzo Capuano Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population Journal of Nutrition and Metabolism |
| title | Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population |
| title_full | Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population |
| title_fullStr | Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population |
| title_full_unstemmed | Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population |
| title_short | Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population |
| title_sort | epidemiologic data of vitamin d deficiency and its implication in cardio cerebrovascular risk in a southern italian population |
| url | http://dx.doi.org/10.1155/2021/5550222 |
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