Direct conversion of peptides into diverse peptidomimetics using a transformer-based chemical language model
The design of pharmaceutically relevant compounds that mimic bioactive peptides or secondary structure elements in proteins is an important task in medicinal chemistry. Over time, various chemical strategies have been developed to convert natural peptide ligands into so-called peptidomimetics. This...
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Main Authors: | Atsushi Yoshimori, Jürgen Bajorath |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-04-01
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Series: | European Journal of Medicinal Chemistry Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417425000056 |
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