Direct conversion of peptides into diverse peptidomimetics using a transformer-based chemical language model

The design of pharmaceutically relevant compounds that mimic bioactive peptides or secondary structure elements in proteins is an important task in medicinal chemistry. Over time, various chemical strategies have been developed to convert natural peptide ligands into so-called peptidomimetics. This...

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Bibliographic Details
Main Authors: Atsushi Yoshimori, Jürgen Bajorath
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000056
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