Dose‐exposure‐response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin‐angiotensin‐aldosterone system in healthy dogs

Dose‐exposure‐response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin‐angiotensin‐aldosterone system in healthy dogs

Abstract Background Benazepril exhibits a dose‐dependent effect on biomarkers of the circulating renin‐angiotensin‐aldosterone system (RAAS) in dogs. Hypothesis/Objectives To characterize the dose‐exposure‐response relationship of a fixed‐dose combination product including benazepril and spironolact...

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Bibliographic Details
Main Authors: Elizabeth Manson, Jessica L. Ward, Maria Merodio, Emilie Guillot, Thomas Blondel, Karin Allenspach, Oliver Domenig, Jonathan P. Mochel
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of Veterinary Internal Medicine
Subjects:
angiotensin‐converting enzyme inhibitor
benazeprilat
canine
canrenone
mineralocorticoid receptor antagonist
TMS
Online Access:https://doi.org/10.1111/jvim.17255
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