Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and Challenges
Abstract. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in numerous confirmed cases and deaths worldwide. Recent studies have shown that people living with HIV (PLWH) are prone to develop severe illness and poor outcomes if they experience coronavirus diseas...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2023-04-01
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| Series: | Infectious Diseases & Immunity |
| Online Access: | http://journals.lww.com/10.1097/ID9.0000000000000073 |
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| author | Jin-Wen Song Lili Shen Fu-Sheng Wang |
| author_facet | Jin-Wen Song Lili Shen Fu-Sheng Wang |
| author_sort | Jin-Wen Song |
| collection | DOAJ |
| description | Abstract. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in numerous confirmed cases and deaths worldwide. Recent studies have shown that people living with HIV (PLWH) are prone to develop severe illness and poor outcomes if they experience coronavirus disease 2019 (COVID-19), especially those with uncontrolled viremia and low CD4 T-cell count. Therefore, many countries prioritized PLWH for COVID-19 vaccination. However, lower magnitude or faster waning humoral immune responses elicited by other vaccines have been documented in PLWH, raising concerns regarding the efficacy of the COVID-19 vaccine in these specific populations. Here, we summarize the current progress in the immunogenicity and efficacy of different types of SARS-CoV-2 vaccinations in PLWH and highlight several challenges faced by PLWH in the current COVID-19 pandemics. |
| format | Article |
| id | doaj-art-728df27ff86e4fe2b9dcc8af9dd74d7a |
| institution | OA Journals |
| issn | 2096-9511 2693-8839 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Infectious Diseases & Immunity |
| spelling | doaj-art-728df27ff86e4fe2b9dcc8af9dd74d7a2025-08-20T02:09:48ZengWolters Kluwer Health - Lippincott Williams WilkinsInfectious Diseases & Immunity2096-95112693-88392023-04-0132909610.1097/ID9.0000000000000073202304000-00007Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and ChallengesJin-Wen Song0Lili Shen1Fu-Sheng Wang21 Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China2 Department of Clinical Medicine, Bengbu Medical College, Bengbu, Anhui 233000, China.1 Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, ChinaAbstract. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in numerous confirmed cases and deaths worldwide. Recent studies have shown that people living with HIV (PLWH) are prone to develop severe illness and poor outcomes if they experience coronavirus disease 2019 (COVID-19), especially those with uncontrolled viremia and low CD4 T-cell count. Therefore, many countries prioritized PLWH for COVID-19 vaccination. However, lower magnitude or faster waning humoral immune responses elicited by other vaccines have been documented in PLWH, raising concerns regarding the efficacy of the COVID-19 vaccine in these specific populations. Here, we summarize the current progress in the immunogenicity and efficacy of different types of SARS-CoV-2 vaccinations in PLWH and highlight several challenges faced by PLWH in the current COVID-19 pandemics.http://journals.lww.com/10.1097/ID9.0000000000000073 |
| spellingShingle | Jin-Wen Song Lili Shen Fu-Sheng Wang Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and Challenges Infectious Diseases & Immunity |
| title | Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and Challenges |
| title_full | Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and Challenges |
| title_fullStr | Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and Challenges |
| title_full_unstemmed | Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and Challenges |
| title_short | Immunogenicity of COVID-19 Vaccination in People Living with HIV: Progress and Challenges |
| title_sort | immunogenicity of covid 19 vaccination in people living with hiv progress and challenges |
| url | http://journals.lww.com/10.1097/ID9.0000000000000073 |
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