Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment
Type 1 diabetes mellitus (T1DM) involves the destruction of pancreatic β-cells, requiring ongoing insulin therapy. A promising alternative for management is pancreatic islet transplantation, or the bioartificial pancreas. Here, we examine the primary implantation sites for the bioartificial pancreas...
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MDPI AG
2025-05-01
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| author | Vinícius Gabriel Silvério Scholl Leonardo Todeschini Justus Otávio Simões Girotto Kelly Karine Pasqual Matheus Henrique Herminio Garcia Fernando Gonçalves da Silva Petronio Aline Flores de Moraes Sandra Maria Barbalho Adriano Cressoni Araújo Lucas Fornari Laurindo Cristina Pires Camargo Maria Angélica Miglino |
| author_facet | Vinícius Gabriel Silvério Scholl Leonardo Todeschini Justus Otávio Simões Girotto Kelly Karine Pasqual Matheus Henrique Herminio Garcia Fernando Gonçalves da Silva Petronio Aline Flores de Moraes Sandra Maria Barbalho Adriano Cressoni Araújo Lucas Fornari Laurindo Cristina Pires Camargo Maria Angélica Miglino |
| author_sort | Vinícius Gabriel Silvério Scholl |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (T1DM) involves the destruction of pancreatic β-cells, requiring ongoing insulin therapy. A promising alternative for management is pancreatic islet transplantation, or the bioartificial pancreas. Here, we examine the primary implantation sites for the bioartificial pancreas, highlighting their anatomical, physical, and immunological characteristics in the context of T1DM treatment. Traditionally used for islet transplantation, the liver promotes metabolic efficiency due to portal drainage; however, it presents issues such as hypoxia and inflammatory responses. The omentum offers excellent vascularization but has limited capacity for subsequent transplants. The renal subcapsular space is advantageous when combined with kidney transplants; however, its use is limited due to low vascularization. The subcutaneous space is notable for its accessibility and lower invasiveness, although its poor vascularization poses significant challenges. These challenges can be mitigated with bioengineering strategies. The gastrointestinal submucosa provides easy access and good vascularization, which makes it a promising option for endoscopic approaches. Additionally, the intrapleural space, which remains underexplored, offers benefits such as increased oxygenation and reduced inflammatory response. Selecting the ideal site for bioartificial pancreas implantation should balance graft support, complication reduction, and surgical accessibility. Bioengineered devices and scaffolds can address the limitations of traditional sites and enhance T1DM management. |
| format | Article |
| id | doaj-art-727ef736fa8c42e2ba6bd3228135a30c |
| institution | DOAJ |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-727ef736fa8c42e2ba6bd3228135a30c2025-08-20T03:14:45ZengMDPI AGBioengineering2306-53542025-05-0112549910.3390/bioengineering12050499Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus TreatmentVinícius Gabriel Silvério Scholl0Leonardo Todeschini Justus1Otávio Simões Girotto2Kelly Karine Pasqual3Matheus Henrique Herminio Garcia4Fernando Gonçalves da Silva Petronio5Aline Flores de Moraes6Sandra Maria Barbalho7Adriano Cressoni Araújo8Lucas Fornari Laurindo9Cristina Pires Camargo10Maria Angélica Miglino11Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilPostgraduate Program in Animal Health, Production and Environment, School of Veterinary Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilMicrosurgery and Plastic Surgery Laboratory (LIM-04), Faculdade de Medicina, Universidade de São Paulo, São Paulo 05508-220, SP, BrazilPostgraduate Program in Animal Health, Production and Environment, School of Veterinary Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, BrazilType 1 diabetes mellitus (T1DM) involves the destruction of pancreatic β-cells, requiring ongoing insulin therapy. A promising alternative for management is pancreatic islet transplantation, or the bioartificial pancreas. Here, we examine the primary implantation sites for the bioartificial pancreas, highlighting their anatomical, physical, and immunological characteristics in the context of T1DM treatment. Traditionally used for islet transplantation, the liver promotes metabolic efficiency due to portal drainage; however, it presents issues such as hypoxia and inflammatory responses. The omentum offers excellent vascularization but has limited capacity for subsequent transplants. The renal subcapsular space is advantageous when combined with kidney transplants; however, its use is limited due to low vascularization. The subcutaneous space is notable for its accessibility and lower invasiveness, although its poor vascularization poses significant challenges. These challenges can be mitigated with bioengineering strategies. The gastrointestinal submucosa provides easy access and good vascularization, which makes it a promising option for endoscopic approaches. Additionally, the intrapleural space, which remains underexplored, offers benefits such as increased oxygenation and reduced inflammatory response. Selecting the ideal site for bioartificial pancreas implantation should balance graft support, complication reduction, and surgical accessibility. Bioengineered devices and scaffolds can address the limitations of traditional sites and enhance T1DM management.https://www.mdpi.com/2306-5354/12/5/499pancreatic islet transplantationdiabetes mellitusartificial pancreasdecellularized pancreasrecellularized pancreas |
| spellingShingle | Vinícius Gabriel Silvério Scholl Leonardo Todeschini Justus Otávio Simões Girotto Kelly Karine Pasqual Matheus Henrique Herminio Garcia Fernando Gonçalves da Silva Petronio Aline Flores de Moraes Sandra Maria Barbalho Adriano Cressoni Araújo Lucas Fornari Laurindo Cristina Pires Camargo Maria Angélica Miglino Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment Bioengineering pancreatic islet transplantation diabetes mellitus artificial pancreas decellularized pancreas recellularized pancreas |
| title | Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment |
| title_full | Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment |
| title_fullStr | Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment |
| title_full_unstemmed | Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment |
| title_short | Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment |
| title_sort | assessing implantation sites for pancreatic islet cell transplantation implications for type 1 diabetes mellitus treatment |
| topic | pancreatic islet transplantation diabetes mellitus artificial pancreas decellularized pancreas recellularized pancreas |
| url | https://www.mdpi.com/2306-5354/12/5/499 |
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