Decrease in platelet count in patients with AKI and its association with major adverse kidney events
Introduction A reduction in platelet count in critically ill patients is a marker of severity of the clinical condition. However, whether this association holds true in acute kidney injury (AKI) is unknown. We analyzed the association between platelet reduction in patients with AKI and major adverse...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2359643 |
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| author | Ramón Medina-González Jose J. Zaragoza Eduardo M. Hernández-Barajas Juarez Correa-de Leon Rolando Claure-Del Granado Armando Vazquez-Rangel Liliana M. Pineda-Segura Martha K. Franco-Garcia Gael Chávez-Alonso Juan A. Gómez-Fregoso Francisco G. Rodríguez-García Guillermo Navarro-Blackaller Luz Alcantar-Vallin Alejandro Martínez Gallardo-González Gabriela J. Abundis-Mora Guillermo García-García Jonathan S. Chávez-Iñiguez |
| author_facet | Ramón Medina-González Jose J. Zaragoza Eduardo M. Hernández-Barajas Juarez Correa-de Leon Rolando Claure-Del Granado Armando Vazquez-Rangel Liliana M. Pineda-Segura Martha K. Franco-Garcia Gael Chávez-Alonso Juan A. Gómez-Fregoso Francisco G. Rodríguez-García Guillermo Navarro-Blackaller Luz Alcantar-Vallin Alejandro Martínez Gallardo-González Gabriela J. Abundis-Mora Guillermo García-García Jonathan S. Chávez-Iñiguez |
| author_sort | Ramón Medina-González |
| collection | DOAJ |
| description | Introduction A reduction in platelet count in critically ill patients is a marker of severity of the clinical condition. However, whether this association holds true in acute kidney injury (AKI) is unknown. We analyzed the association between platelet reduction in patients with AKI and major adverse kidney events (MAKE).Methods In this retrospective cohort, we included AKI patients at the Hospital Civil of Guadalajara, in Jalisco, Mexico. Patients were divided according to whether their platelet count fell >21% during the first 10 days. Our objectives were to analyze the associations between a platelet reduction >21% and MAKE at 10 days (MAKE10) or at 30-90 days (MAKE30-90) and death.Results From 2017 to 2023, 400 AKI patients were included, 134 of whom had a > 21% reduction in platelet count. The mean age was 54 years, 60% were male, and 44% had sepsis. The mean baseline platelet count was 194 x 103 cells/µL, and 65% of the KDIGO3 patients met these criteria. Those who underwent hemodialysis (HD) had lower platelet counts. After multiple adjustments, a platelet reduction >21% was associated with MAKE10 (OR 4.2, CI 2.1-8.5) but not with MAKE30-90. The mortality risk increased 3-fold (OR 2.9, CI 1.1-7.7, p = 0.02) with a greater decrease in the platelets (<90 x 103 cells/µL). As the platelets decreased, the incidence of MAKE was more likely to increase. These associations lost significance when accounting for starting HD.Conclusion In our retrospective cohort of patients with AKI, a > 21% reduction in platelet count was associated with MAKE. Our results are useful for generating hypotheses and motivating us to continue studying this association with a more robust design. |
| format | Article |
| id | doaj-art-727b965aa94f45f387bb77748d6e0091 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Renal Failure |
| spelling | doaj-art-727b965aa94f45f387bb77748d6e00912025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2359643Decrease in platelet count in patients with AKI and its association with major adverse kidney eventsRamón Medina-González0Jose J. Zaragoza1Eduardo M. Hernández-Barajas2Juarez Correa-de Leon3Rolando Claure-Del Granado4Armando Vazquez-Rangel5Liliana M. Pineda-Segura6Martha K. Franco-Garcia7Gael Chávez-Alonso8Juan A. Gómez-Fregoso9Francisco G. Rodríguez-García10Guillermo Navarro-Blackaller11Luz Alcantar-Vallin12Alejandro Martínez Gallardo-González13Gabriela J. Abundis-Mora14Guillermo García-García15Jonathan S. Chávez-Iñiguez16Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoIntensive Care Unit, Hospital H + Queretaro, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoDivision of Nephrology, Hospital Obrero No 2 – CNS. IIBISMED, Facultad de Medicina, Universidad Mayor de San Simon, Cochabamba, BoliviaDepartment of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoUniversity of Guadalajara Health Sciences Center, Guadalajara, Jalisco, MexicoUniversity of Guadalajara Health Sciences Center, Guadalajara, Jalisco, MexicoUniversity of Guadalajara Health Sciences Center, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoUniversity of Guadalajara Health Sciences Center, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoIntroduction A reduction in platelet count in critically ill patients is a marker of severity of the clinical condition. However, whether this association holds true in acute kidney injury (AKI) is unknown. We analyzed the association between platelet reduction in patients with AKI and major adverse kidney events (MAKE).Methods In this retrospective cohort, we included AKI patients at the Hospital Civil of Guadalajara, in Jalisco, Mexico. Patients were divided according to whether their platelet count fell >21% during the first 10 days. Our objectives were to analyze the associations between a platelet reduction >21% and MAKE at 10 days (MAKE10) or at 30-90 days (MAKE30-90) and death.Results From 2017 to 2023, 400 AKI patients were included, 134 of whom had a > 21% reduction in platelet count. The mean age was 54 years, 60% were male, and 44% had sepsis. The mean baseline platelet count was 194 x 103 cells/µL, and 65% of the KDIGO3 patients met these criteria. Those who underwent hemodialysis (HD) had lower platelet counts. After multiple adjustments, a platelet reduction >21% was associated with MAKE10 (OR 4.2, CI 2.1-8.5) but not with MAKE30-90. The mortality risk increased 3-fold (OR 2.9, CI 1.1-7.7, p = 0.02) with a greater decrease in the platelets (<90 x 103 cells/µL). As the platelets decreased, the incidence of MAKE was more likely to increase. These associations lost significance when accounting for starting HD.Conclusion In our retrospective cohort of patients with AKI, a > 21% reduction in platelet count was associated with MAKE. Our results are useful for generating hypotheses and motivating us to continue studying this association with a more robust design.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2359643Acute kidney injuryplateletsthrombocytopeniamajor adverse kidney eventshemodialysis |
| spellingShingle | Ramón Medina-González Jose J. Zaragoza Eduardo M. Hernández-Barajas Juarez Correa-de Leon Rolando Claure-Del Granado Armando Vazquez-Rangel Liliana M. Pineda-Segura Martha K. Franco-Garcia Gael Chávez-Alonso Juan A. Gómez-Fregoso Francisco G. Rodríguez-García Guillermo Navarro-Blackaller Luz Alcantar-Vallin Alejandro Martínez Gallardo-González Gabriela J. Abundis-Mora Guillermo García-García Jonathan S. Chávez-Iñiguez Decrease in platelet count in patients with AKI and its association with major adverse kidney events Renal Failure Acute kidney injury platelets thrombocytopenia major adverse kidney events hemodialysis |
| title | Decrease in platelet count in patients with AKI and its association with major adverse kidney events |
| title_full | Decrease in platelet count in patients with AKI and its association with major adverse kidney events |
| title_fullStr | Decrease in platelet count in patients with AKI and its association with major adverse kidney events |
| title_full_unstemmed | Decrease in platelet count in patients with AKI and its association with major adverse kidney events |
| title_short | Decrease in platelet count in patients with AKI and its association with major adverse kidney events |
| title_sort | decrease in platelet count in patients with aki and its association with major adverse kidney events |
| topic | Acute kidney injury platelets thrombocytopenia major adverse kidney events hemodialysis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2359643 |
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