Use of tacrolimus to prevent acute kidney graft rejection in sensitized patients
The emergence of new immunosuppressants, such as the macrolide drug tacrolimus (prograf), has recently become one of the most important advances in transplantology. Tacrolimus belongs to calcineurin inhibitors and differs from cyclosporine in a rapider and uniform bile acid-independent absorption, c...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2018-08-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/255 |
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| author | O. N. Rzhevskaya A. V. Pinchuk R. V. Storozhev I. V. Dmitriev |
| author_facet | O. N. Rzhevskaya A. V. Pinchuk R. V. Storozhev I. V. Dmitriev |
| author_sort | O. N. Rzhevskaya |
| collection | DOAJ |
| description | The emergence of new immunosuppressants, such as the macrolide drug tacrolimus (prograf), has recently become one of the most important advances in transplantology. Tacrolimus belongs to calcineurin inhibitors and differs from cyclosporine in a rapider and uniform bile acid-independent absorption, causing a reduction in the individual variability of the blood concentration of the active ingredient. On renal transplantation in sensitized patients and/or repeated allografting, the use of tacrolimus makes it possible to reduce the percentage of hormone-resistant crises by more than twice and to prevent intractable acute rejection crisis. |
| format | Article |
| id | doaj-art-72669281ad9f424b97895e18fd8fae3a |
| institution | DOAJ |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-72669281ad9f424b97895e18fd8fae3a2025-08-20T02:55:45ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092018-08-0102515310.23873/2074-0506-2009-0-2-51-53244Use of tacrolimus to prevent acute kidney graft rejection in sensitized patientsO. N. Rzhevskaya0A. V. Pinchuk1R. V. Storozhev2I. V. Dmitriev3N.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryN.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryN.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryN.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryThe emergence of new immunosuppressants, such as the macrolide drug tacrolimus (prograf), has recently become one of the most important advances in transplantology. Tacrolimus belongs to calcineurin inhibitors and differs from cyclosporine in a rapider and uniform bile acid-independent absorption, causing a reduction in the individual variability of the blood concentration of the active ingredient. On renal transplantation in sensitized patients and/or repeated allografting, the use of tacrolimus makes it possible to reduce the percentage of hormone-resistant crises by more than twice and to prevent intractable acute rejection crisis.https://www.jtransplantologiya.ru/jour/article/view/255allograftingimmunosuppressantscalcineurin inhibitorstacrolimuscyclosporineacute rejection crisis |
| spellingShingle | O. N. Rzhevskaya A. V. Pinchuk R. V. Storozhev I. V. Dmitriev Use of tacrolimus to prevent acute kidney graft rejection in sensitized patients Трансплантология (Москва) allografting immunosuppressants calcineurin inhibitors tacrolimus cyclosporine acute rejection crisis |
| title | Use of tacrolimus to prevent acute kidney graft rejection in sensitized patients |
| title_full | Use of tacrolimus to prevent acute kidney graft rejection in sensitized patients |
| title_fullStr | Use of tacrolimus to prevent acute kidney graft rejection in sensitized patients |
| title_full_unstemmed | Use of tacrolimus to prevent acute kidney graft rejection in sensitized patients |
| title_short | Use of tacrolimus to prevent acute kidney graft rejection in sensitized patients |
| title_sort | use of tacrolimus to prevent acute kidney graft rejection in sensitized patients |
| topic | allografting immunosuppressants calcineurin inhibitors tacrolimus cyclosporine acute rejection crisis |
| url | https://www.jtransplantologiya.ru/jour/article/view/255 |
| work_keys_str_mv | AT onrzhevskaya useoftacrolimustopreventacutekidneygraftrejectioninsensitizedpatients AT avpinchuk useoftacrolimustopreventacutekidneygraftrejectioninsensitizedpatients AT rvstorozhev useoftacrolimustopreventacutekidneygraftrejectioninsensitizedpatients AT ivdmitriev useoftacrolimustopreventacutekidneygraftrejectioninsensitizedpatients |