Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis
Purpura fulminans (PF) is a rare skin disorder with extensive areas of blueblack hemorrhagic necrosis. Patients manifest typical laboratory signs of disseminated intravascular coagulation (DIC). Our case describes a 37-year-old previously healthy man who presented with 3 days of generalized malaise,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2012/508503 |
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| _version_ | 1832555342488141824 |
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| author | Erick F. Alvarez Karen E. Olarte Mayur S. Ramesh |
| author_facet | Erick F. Alvarez Karen E. Olarte Mayur S. Ramesh |
| author_sort | Erick F. Alvarez |
| collection | DOAJ |
| description | Purpura fulminans (PF) is a rare skin disorder with extensive areas of blueblack hemorrhagic necrosis. Patients manifest typical laboratory signs of disseminated intravascular coagulation (DIC). Our case describes a 37-year-old previously healthy man who presented with 3 days of generalized malaise, headache, vomiting, photophobia, and an ecchymotic skin rash. Initial laboratory workup revealed DIC without obvious infectious trigger including unremarkable cerebrospinal fluid (CSF) biochemical analysis. There was further progression of the skin ecchymosis and multiorgan damage consistent with PF. Final CSF cultures revealed Streptococcus pneumoniae. Despite normal initial CSF biochemical analysis, bacterial meningitis should always be considered in patients with otherwise unexplained DIC as this may be an early manifestation of infection. PF is a clinical diagnosis that requires early recognition and prompt empirical treatment, especially, in patients with progressive altered mental status, ecchymotic skin rash, and DIC. |
| format | Article |
| id | doaj-art-724965f6b37c4028a3fb54ed6539d918 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-724965f6b37c4028a3fb54ed6539d9182025-02-03T05:48:26ZengWileyCase Reports in Infectious Diseases2090-66252090-66332012-01-01201210.1155/2012/508503508503Purpura Fulminans Secondary to Streptococcus pneumoniae MeningitisErick F. Alvarez0Karen E. Olarte1Mayur S. Ramesh2Infectious Diseases Division, Henry Ford Hospital, 2799 W. Grand Blvd., Detroit, MI 48202, USAInternal Medicine Residency Program, Henry Ford Hospital, Detroit, MI 48202, USAInfectious Diseases Division, Henry Ford Hospital, 2799 W. Grand Blvd., Detroit, MI 48202, USAPurpura fulminans (PF) is a rare skin disorder with extensive areas of blueblack hemorrhagic necrosis. Patients manifest typical laboratory signs of disseminated intravascular coagulation (DIC). Our case describes a 37-year-old previously healthy man who presented with 3 days of generalized malaise, headache, vomiting, photophobia, and an ecchymotic skin rash. Initial laboratory workup revealed DIC without obvious infectious trigger including unremarkable cerebrospinal fluid (CSF) biochemical analysis. There was further progression of the skin ecchymosis and multiorgan damage consistent with PF. Final CSF cultures revealed Streptococcus pneumoniae. Despite normal initial CSF biochemical analysis, bacterial meningitis should always be considered in patients with otherwise unexplained DIC as this may be an early manifestation of infection. PF is a clinical diagnosis that requires early recognition and prompt empirical treatment, especially, in patients with progressive altered mental status, ecchymotic skin rash, and DIC.http://dx.doi.org/10.1155/2012/508503 |
| spellingShingle | Erick F. Alvarez Karen E. Olarte Mayur S. Ramesh Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis Case Reports in Infectious Diseases |
| title | Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis |
| title_full | Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis |
| title_fullStr | Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis |
| title_full_unstemmed | Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis |
| title_short | Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis |
| title_sort | purpura fulminans secondary to streptococcus pneumoniae meningitis |
| url | http://dx.doi.org/10.1155/2012/508503 |
| work_keys_str_mv | AT erickfalvarez purpurafulminanssecondarytostreptococcuspneumoniaemeningitis AT kareneolarte purpurafulminanssecondarytostreptococcuspneumoniaemeningitis AT mayursramesh purpurafulminanssecondarytostreptococcuspneumoniaemeningitis |