Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological evaluation

Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological evaluation

Considering the essential role of FLT3-ITD mutations in the development of acute myeloid leukemia (AML), the research and development of FLT3 inhibitors hold significant therapeutic potential. In this study, we identified a novel, highly potent small molecule inhibitor, FLIN-4, targeting FLT3 throug...

Full description

Saved in:
Bibliographic Details
Main Authors: Kun Shi, Ye Hong, Huajing Liu, Xiaotian Yang, Fengzhen Wang, Yanming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
FLT3-ITD mutation
acute myeloid leukemia (AML)
small molecule inhibitor
structure-based virtual screening
biological evaluation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1511257/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items