Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity
Background Determining the status of nonsegmental vitiligo is crucial in initiating the management plan, especially when planning for surgery. Serum biomarkers can serve as an additive tool, to clinical examination and history-taking, in differentiating active from stable vitiligo. Objective To asse...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of the Egyptian Women’s Dermatologic Society |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jewd.jewd_68_24 |
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| author | Dalia A. Bassiouny Yasmin B. El Zawahry Ahmed M. Soliman Alaa H. Sayed Eman R. Youness Dina G. Saadi |
| author_facet | Dalia A. Bassiouny Yasmin B. El Zawahry Ahmed M. Soliman Alaa H. Sayed Eman R. Youness Dina G. Saadi |
| author_sort | Dalia A. Bassiouny |
| collection | DOAJ |
| description | Background
Determining the status of nonsegmental vitiligo is crucial in initiating the management plan, especially when planning for surgery. Serum biomarkers can serve as an additive tool, to clinical examination and history-taking, in differentiating active from stable vitiligo.
Objective
To assess serum levels of calprotectin (CP) in nonsegmental vitiligo, and to compare these levels among active and stable cases.
Patients and methods
Serum samples were taken from 42 vitiligo patients and 42 healthy controls, and CP levels were measured by ELISA technique.
Results
Although the serum CP levels were not significantly higher in patients (median = 33.6) in comparison with controls (median = 33.5) (P=0.28), CP was significantly elevated in active vitiligo cases when compared with stable patients (P=0.010) and had a positive correlation with vitiligo disease activity score (r=0.400, P=0.009).
Conclusion
Serum CP can potentially help in differentiating active from stable vitiligo. |
| format | Article |
| id | doaj-art-7235ccd448324bd592224b4f6c1ab43f |
| institution | Kabale University |
| issn | 2090-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Egyptian Women’s Dermatologic Society |
| spelling | doaj-art-7235ccd448324bd592224b4f6c1ab43f2025-01-20T04:38:20ZengWolters Kluwer Medknow PublicationsJournal of the Egyptian Women’s Dermatologic Society2090-25652025-01-01221404610.4103/jewd.jewd_68_24Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activityDalia A. BassiounyYasmin B. El ZawahryAhmed M. SolimanAlaa H. SayedEman R. YounessDina G. SaadiBackground Determining the status of nonsegmental vitiligo is crucial in initiating the management plan, especially when planning for surgery. Serum biomarkers can serve as an additive tool, to clinical examination and history-taking, in differentiating active from stable vitiligo. Objective To assess serum levels of calprotectin (CP) in nonsegmental vitiligo, and to compare these levels among active and stable cases. Patients and methods Serum samples were taken from 42 vitiligo patients and 42 healthy controls, and CP levels were measured by ELISA technique. Results Although the serum CP levels were not significantly higher in patients (median = 33.6) in comparison with controls (median = 33.5) (P=0.28), CP was significantly elevated in active vitiligo cases when compared with stable patients (P=0.010) and had a positive correlation with vitiligo disease activity score (r=0.400, P=0.009). Conclusion Serum CP can potentially help in differentiating active from stable vitiligo.https://journals.lww.com/10.4103/jewd.jewd_68_24alarmincalprotectinnonsegmental vitiligo |
| spellingShingle | Dalia A. Bassiouny Yasmin B. El Zawahry Ahmed M. Soliman Alaa H. Sayed Eman R. Youness Dina G. Saadi Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity Journal of the Egyptian Women’s Dermatologic Society alarmin calprotectin nonsegmental vitiligo |
| title | Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity |
| title_full | Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity |
| title_fullStr | Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity |
| title_full_unstemmed | Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity |
| title_short | Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity |
| title_sort | serum calprotectin in nonsegmental vitiligo a possible marker of disease activity |
| topic | alarmin calprotectin nonsegmental vitiligo |
| url | https://journals.lww.com/10.4103/jewd.jewd_68_24 |
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