Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity
Background Determining the status of nonsegmental vitiligo is crucial in initiating the management plan, especially when planning for surgery. Serum biomarkers can serve as an additive tool, to clinical examination and history-taking, in differentiating active from stable vitiligo. Objective To asse...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of the Egyptian Women’s Dermatologic Society |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jewd.jewd_68_24 |
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| Summary: | Background
Determining the status of nonsegmental vitiligo is crucial in initiating the management plan, especially when planning for surgery. Serum biomarkers can serve as an additive tool, to clinical examination and history-taking, in differentiating active from stable vitiligo.
Objective
To assess serum levels of calprotectin (CP) in nonsegmental vitiligo, and to compare these levels among active and stable cases.
Patients and methods
Serum samples were taken from 42 vitiligo patients and 42 healthy controls, and CP levels were measured by ELISA technique.
Results
Although the serum CP levels were not significantly higher in patients (median = 33.6) in comparison with controls (median = 33.5) (P=0.28), CP was significantly elevated in active vitiligo cases when compared with stable patients (P=0.010) and had a positive correlation with vitiligo disease activity score (r=0.400, P=0.009).
Conclusion
Serum CP can potentially help in differentiating active from stable vitiligo. |
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| ISSN: | 2090-2565 |