Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients
Objective Malnutrition and inflammation are associated with mortality in peritoneal dialysis (PD) patients. Serum albumin and non-high-density lipoprotein cholesterol (non-HDL-C) are independently associated with mortality in PD patients. Combining albumin and non-HDL-C with mortality may be more pl...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2299601 |
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| _version_ | 1832591102823104512 |
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| author | Yongjie Xie Xiaoran Feng Youqun Gao Xiaojiang Zhan Fenfen Peng Qian Zhou Xianfeng Wu Xiaoyang Wang Na Tian Qingdong Xu Ning Su Xingming Tang Jianbo Liang Jiao Li Yueqiang Wen |
| author_facet | Yongjie Xie Xiaoran Feng Youqun Gao Xiaojiang Zhan Fenfen Peng Qian Zhou Xianfeng Wu Xiaoyang Wang Na Tian Qingdong Xu Ning Su Xingming Tang Jianbo Liang Jiao Li Yueqiang Wen |
| author_sort | Yongjie Xie |
| collection | DOAJ |
| description | Objective Malnutrition and inflammation are associated with mortality in peritoneal dialysis (PD) patients. Serum albumin and non-high-density lipoprotein cholesterol (non-HDL-C) are independently associated with mortality in PD patients. Combining albumin and non-HDL-C with mortality may be more plausible in clinical practice.Methods This retrospective cohort study included 1954 Chinese PD patients from 1 January 2009 to 31 December 2016. Kaplan–Meier curve was used to determine the relationship between albumin to non-HDL-C ratio and all-cause mortality. Cox regression analysis was applied to assess the independent predictive value while adjusting for confounding factors. Competitive risk analysis was used to examine the effects of other outcomes on all-cause mortality prognosis.Results In the 33-month follow-up period, there were 538 all-cause deaths. Kaplan–Meier analysis presented significant differences in all-cause mortality. Multivariate Cox regression showed that the risk of all-cause mortality was lower in the moderate group (9.36–12.79) (HR, 0.731; 95% CI, 0.593–0.902, p = 0.004) and the highest group (>12.79) (HR, 0.705; 95% CI, 0.565–0.879, p = 0.002) compared to the lowest group (≤9.36). Competitive risk analysis revealed significant differences for all-cause mortality (p < 0.001), while there was no statistical significance for other competing events.Conclusions Low albumin to non-HDL-C ratio was associated with a high risk of all-cause mortality in PD patients. It may serve as a potential prognostic biomarker in PD patients. |
| format | Article |
| id | doaj-art-722a214fd2f44de39a81686f762f1967 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-722a214fd2f44de39a81686f762f19672025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2299601Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patientsYongjie Xie0Xiaoran Feng1Youqun Gao2Xiaojiang Zhan3Fenfen Peng4Qian Zhou5Xianfeng Wu6Xiaoyang Wang7Na Tian8Qingdong Xu9Ning Su10Xingming Tang11Jianbo Liang12Jiao Li13Yueqiang Wen14Department of Nephrology, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, PR ChinaDepartment of Nephrology, Jiujiang NO.1 People’s Hospital, Jiangxi, PR ChinaDepartment of Nephrology, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, PR ChinaDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, PR ChinaDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, PR ChinaDepartment of Medical Statistics, Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaDepartment of Nephrology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, PR ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, PR ChinaDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, PR ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen, PR ChinaDepartment of Hematology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR ChinaDepartment of Nephropathy and Rheumatism, Dongguan Songshan Lake Tungwah Hospital, Dongguan, PR ChinaDepartment of Nephrology, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, PR ChinaDepartment of Nephrology, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, PR ChinaDepartment of Nephrology, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, PR ChinaObjective Malnutrition and inflammation are associated with mortality in peritoneal dialysis (PD) patients. Serum albumin and non-high-density lipoprotein cholesterol (non-HDL-C) are independently associated with mortality in PD patients. Combining albumin and non-HDL-C with mortality may be more plausible in clinical practice.Methods This retrospective cohort study included 1954 Chinese PD patients from 1 January 2009 to 31 December 2016. Kaplan–Meier curve was used to determine the relationship between albumin to non-HDL-C ratio and all-cause mortality. Cox regression analysis was applied to assess the independent predictive value while adjusting for confounding factors. Competitive risk analysis was used to examine the effects of other outcomes on all-cause mortality prognosis.Results In the 33-month follow-up period, there were 538 all-cause deaths. Kaplan–Meier analysis presented significant differences in all-cause mortality. Multivariate Cox regression showed that the risk of all-cause mortality was lower in the moderate group (9.36–12.79) (HR, 0.731; 95% CI, 0.593–0.902, p = 0.004) and the highest group (>12.79) (HR, 0.705; 95% CI, 0.565–0.879, p = 0.002) compared to the lowest group (≤9.36). Competitive risk analysis revealed significant differences for all-cause mortality (p < 0.001), while there was no statistical significance for other competing events.Conclusions Low albumin to non-HDL-C ratio was associated with a high risk of all-cause mortality in PD patients. It may serve as a potential prognostic biomarker in PD patients.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2299601Albuminnon-high-density lipoprotein cholesterolmortalityperitoneal dialysisinflammationnutrition |
| spellingShingle | Yongjie Xie Xiaoran Feng Youqun Gao Xiaojiang Zhan Fenfen Peng Qian Zhou Xianfeng Wu Xiaoyang Wang Na Tian Qingdong Xu Ning Su Xingming Tang Jianbo Liang Jiao Li Yueqiang Wen Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients Renal Failure Albumin non-high-density lipoprotein cholesterol mortality peritoneal dialysis inflammation nutrition |
| title | Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients |
| title_full | Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients |
| title_fullStr | Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients |
| title_full_unstemmed | Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients |
| title_short | Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients |
| title_sort | association of albumin to non high density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients |
| topic | Albumin non-high-density lipoprotein cholesterol mortality peritoneal dialysis inflammation nutrition |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2299601 |
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