The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization
Although the cellular and molecular mechanisms of tumor growth and metastasis are not completely understood, it is established that formation and growth of new blood vessels is a conditio sine qua non for tumor survival, growth, and expansion. Numerous studies over the past decades demonstrated that...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.100 |
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| _version_ | 1832550701888176128 |
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| author | Branislava Janic Ali S. Arbab |
| author_facet | Branislava Janic Ali S. Arbab |
| author_sort | Branislava Janic |
| collection | DOAJ |
| description | Although the cellular and molecular mechanisms of tumor growth and metastasis are not completely understood, it is established that formation and growth of new blood vessels is a conditio sine qua non for tumor survival, growth, and expansion. Numerous studies over the past decades demonstrated that neovascularization associated with tumor growth occurs via angiogenic and vasculogenic mechanisms that involve sprouting angiogenesis, intussusceptive angiogenesis, vessel co-option, vasculogenic mimicry, lymphangiogenesis, and the recruitment of endothelial progenitor cells (EPCs). Due to their ability to self-renew, circulate, home to the ischemic sites, and differentiate into mature endothelial cells, EPCs hold enormous potential to be used as a diagnostic and/or therapeutic agent in antitumor therapies. Hence, this review focuses on EPCs and their role in tumor angiogenesis with the emphasis on EPC recruitment/migration, and the potential use of EPCs as a therapeutic tool and imaging probe. |
| format | Article |
| id | doaj-art-721a13f43c1241a18777a910e17b146f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-721a13f43c1241a18777a910e17b146f2025-02-03T06:05:58ZengWileyThe Scientific World Journal1537-744X2010-01-01101088109910.1100/tsw.2010.100The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor NeovascularizationBranislava Janic0Ali S. Arbab1Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI, USACellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI, USAAlthough the cellular and molecular mechanisms of tumor growth and metastasis are not completely understood, it is established that formation and growth of new blood vessels is a conditio sine qua non for tumor survival, growth, and expansion. Numerous studies over the past decades demonstrated that neovascularization associated with tumor growth occurs via angiogenic and vasculogenic mechanisms that involve sprouting angiogenesis, intussusceptive angiogenesis, vessel co-option, vasculogenic mimicry, lymphangiogenesis, and the recruitment of endothelial progenitor cells (EPCs). Due to their ability to self-renew, circulate, home to the ischemic sites, and differentiate into mature endothelial cells, EPCs hold enormous potential to be used as a diagnostic and/or therapeutic agent in antitumor therapies. Hence, this review focuses on EPCs and their role in tumor angiogenesis with the emphasis on EPC recruitment/migration, and the potential use of EPCs as a therapeutic tool and imaging probe.http://dx.doi.org/10.1100/tsw.2010.100 |
| spellingShingle | Branislava Janic Ali S. Arbab The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization The Scientific World Journal |
| title | The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization |
| title_full | The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization |
| title_fullStr | The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization |
| title_full_unstemmed | The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization |
| title_short | The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization |
| title_sort | role and therapeutic potential of endothelial progenitor cells in tumor neovascularization |
| url | http://dx.doi.org/10.1100/tsw.2010.100 |
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