Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder

Abstract Cortisol dysregulation plays a critical role in the pathophysiology of depression, but its exact impact on the brain remains unclear. In this cross-sectional study, 210 participants, including 164 depressed patients and 46 healthy controls (HCs), were assessed. Glymphatic circulation was ev...

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Bibliographic Details
Main Authors: Shengli Chen, Ziyun Xu, Zheng Guo, Shiwei Lin, Hongyuan Zhang, Qunjun Liang, Qianyun Chen, Yingli Zhang, Bo Peng, Yanzhen Zhao, Gangqiang Hou, Yingwei Qiu
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03486-1
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