Retained introns in phototransduction genes of 5xFAD mouse retina suggest vision impairment as an early diagnostic marker for Alzheimer’s disease

Retained introns in phototransduction genes of 5xFAD mouse retina suggest vision impairment as an early diagnostic marker for Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by neuronal and synaptic loss in the brain, which leads to cognitive impairment and dementia. Therefore, early diagnosis by employing various biomarkers is crucial for preventing and treating AD. Although re...

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Main Authors: Hyun-Min Lee, Jinho Kim, Ji-Young Kim, Mi-Jin An, Geun-Seup Shin, Ah-Ra Jo, Yuna Park, Chul-Hong Kim, Yujeong Hwangbo, Ju-Hyun Lee, Tae Kyung Hong, Kun Ho Lee, Sangmyung Rhee, Jung-Woong Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease (AD)
Retina
Alternative splicing
Retained intron
5xFAD
Online Access:https://doi.org/10.1038/s41598-025-11065-z
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https://doi.org/10.1038/s41598-025-11065-z

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