Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population
Abstract Background Pelvic organ prolapse (POP) occurs when one or more pelvic organs (uterus, bowel, bladder or top of the vagina) descend from their normal position and bulge into the vagina. Symptoms include pelvic discomfort, fullness, and changes in bladder or bowel function. Treatment ranges f...
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2025-01-01
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| Online Access: | https://doi.org/10.1002/bco2.464 |
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| author | Tharanga Mudalige Vindya Pathiraja Gayathri Delanerolle Heitor Cavalini Shuqi Wu Julie Taylor Om Kurmi Kathryn Elliot Sharron Hinchliff Carol Atkinson Kristina Potocnik Paula Briggs Lucky Saraswat Helen Felicity Kemp George Eleje Toh Teck Hock Cristina Laguna Benetti‐Pinto Irfan Muhammad Rabia Kareem Yassine Bouchareb Peter Phiri Ruishu Zhang Yunfei Weng Ieera Aggarwal Jian Qing Shi Ashish Shetty Ian Litchfield Nirmala Rathnayake Sohier Elneil |
| author_facet | Tharanga Mudalige Vindya Pathiraja Gayathri Delanerolle Heitor Cavalini Shuqi Wu Julie Taylor Om Kurmi Kathryn Elliot Sharron Hinchliff Carol Atkinson Kristina Potocnik Paula Briggs Lucky Saraswat Helen Felicity Kemp George Eleje Toh Teck Hock Cristina Laguna Benetti‐Pinto Irfan Muhammad Rabia Kareem Yassine Bouchareb Peter Phiri Ruishu Zhang Yunfei Weng Ieera Aggarwal Jian Qing Shi Ashish Shetty Ian Litchfield Nirmala Rathnayake Sohier Elneil |
| author_sort | Tharanga Mudalige |
| collection | DOAJ |
| description | Abstract Background Pelvic organ prolapse (POP) occurs when one or more pelvic organs (uterus, bowel, bladder or top of the vagina) descend from their normal position and bulge into the vagina. Symptoms include pelvic discomfort, fullness, and changes in bladder or bowel function. Treatment ranges from conservative approaches to surgery, depending on symptom severity. Surgical methods include vaginal wall repair, with or without hysterectomy, or via laparoscopic, robotic or open techniques. Common complications include bleeding, infection, and urinary or bowel dysfunction. Methods A systematic review was conducted, and a protocol was registered with PROSPERO (CRD42022346051). Publications from 30 April 1980 to 30 April 2023 were retrieved from multiple databases. Data were analysed using random‐effects and common‐effects models with subgroup and sensitivity analyses. Findings Forty‐four studies met the inclusion criteria, with 29 studies used for meta‐analysis of vaginal prolapse surgery outcomes. Sixteen studies focused on patients who had undergone hysterectomy alongside prolapse repair. Interpretation Patients who underwent vaginal prolapse surgery with hysterectomy experienced higher operative and postoperative complication rates than those without hysterectomy. Increased risks included hospital readmission, POP recurrence and re‐operation. The review highlighted a lack of diversity in terms of ethnicity, age and comorbidity status, which are essential to fully understanding the impact of POP. Future research should focus on these underrepresented factors. |
| format | Article |
| id | doaj-art-7209ff41fd2b461bb60267d58c158f26 |
| institution | Kabale University |
| issn | 2688-4526 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | BJUI Compass |
| spelling | doaj-art-7209ff41fd2b461bb60267d58c158f262025-01-31T00:14:32ZengWileyBJUI Compass2688-45262025-01-0161n/an/a10.1002/bco2.464Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global populationTharanga Mudalige0Vindya Pathiraja1Gayathri Delanerolle2Heitor Cavalini3Shuqi Wu4Julie Taylor5Om Kurmi6Kathryn Elliot7Sharron Hinchliff8Carol Atkinson9Kristina Potocnik10Paula Briggs11Lucky Saraswat12Helen Felicity Kemp13George Eleje14Toh Teck Hock15Cristina Laguna Benetti‐Pinto16Irfan Muhammad17Rabia Kareem18Yassine Bouchareb19Peter Phiri20Ruishu Zhang21Yunfei Weng22Ieera Aggarwal23Jian Qing Shi24Ashish Shetty25Ian Litchfield26Nirmala Rathnayake27Sohier Elneil28University of Ruhuna Matara Sri LankaUniversity of Ruhuna Matara Sri LankaSouthern Health NHS Foundation Trust Southampton UKSouthern Health NHS Foundation Trust Southampton UKSouthern University of Science and Technology Shenzhen ChinaUniversity of Birmingham Birmingham UKUniversity of Coventry Coventry UKSouthern Health NHS Foundation Trust Southampton UKUniversity of Sheffield Sheffield UKUniversity of Sheffield Sheffield UKUniversity of Edinburgh Edinburgh Scotland UKDepartment of Women's and Children's Health University of Liverpool Liverpool UKUniversity of Aberdeen Aberdeen Scotland UKNo affiliationNnamdi Azikiwe University Nnewi NigeriaSibu Hospital Sibu Sarawak MalaysiaUniversity of Campinas, UNICAMP Campinas BrazilPeshawar Medical College Riphah International University Islamabad PakistanPeshawar Medical College Riphah International University Islamabad PakistanSultan Qaboos University Muscat OmanSouthern Health NHS Foundation Trust Southampton UKSultan Qaboos University Muscat OmanSultan Qaboos University Muscat OmanKK Women's and Children's Hospital SingaporeSouthern Health NHS Foundation Trust Southampton UKUniversity of Ruhuna Matara Sri LankaUniversity of Birmingham Birmingham UKManchester Metropolitan University Manchester UKUniversity College London Hospitals NHS Foundation Trust London UKAbstract Background Pelvic organ prolapse (POP) occurs when one or more pelvic organs (uterus, bowel, bladder or top of the vagina) descend from their normal position and bulge into the vagina. Symptoms include pelvic discomfort, fullness, and changes in bladder or bowel function. Treatment ranges from conservative approaches to surgery, depending on symptom severity. Surgical methods include vaginal wall repair, with or without hysterectomy, or via laparoscopic, robotic or open techniques. Common complications include bleeding, infection, and urinary or bowel dysfunction. Methods A systematic review was conducted, and a protocol was registered with PROSPERO (CRD42022346051). Publications from 30 April 1980 to 30 April 2023 were retrieved from multiple databases. Data were analysed using random‐effects and common‐effects models with subgroup and sensitivity analyses. Findings Forty‐four studies met the inclusion criteria, with 29 studies used for meta‐analysis of vaginal prolapse surgery outcomes. Sixteen studies focused on patients who had undergone hysterectomy alongside prolapse repair. Interpretation Patients who underwent vaginal prolapse surgery with hysterectomy experienced higher operative and postoperative complication rates than those without hysterectomy. Increased risks included hospital readmission, POP recurrence and re‐operation. The review highlighted a lack of diversity in terms of ethnicity, age and comorbidity status, which are essential to fully understanding the impact of POP. Future research should focus on these underrepresented factors.https://doi.org/10.1002/bco2.464gynaecologypelvic organ prolapseurologywellbeingwomen's health |
| spellingShingle | Tharanga Mudalige Vindya Pathiraja Gayathri Delanerolle Heitor Cavalini Shuqi Wu Julie Taylor Om Kurmi Kathryn Elliot Sharron Hinchliff Carol Atkinson Kristina Potocnik Paula Briggs Lucky Saraswat Helen Felicity Kemp George Eleje Toh Teck Hock Cristina Laguna Benetti‐Pinto Irfan Muhammad Rabia Kareem Yassine Bouchareb Peter Phiri Ruishu Zhang Yunfei Weng Ieera Aggarwal Jian Qing Shi Ashish Shetty Ian Litchfield Nirmala Rathnayake Sohier Elneil Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population BJUI Compass gynaecology pelvic organ prolapse urology wellbeing women's health |
| title | Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population |
| title_full | Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population |
| title_fullStr | Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population |
| title_full_unstemmed | Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population |
| title_short | Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population |
| title_sort | systematic review and meta analysis of the pelvic organ prolapse and vaginal prolapse among the global population |
| topic | gynaecology pelvic organ prolapse urology wellbeing women's health |
| url | https://doi.org/10.1002/bco2.464 |
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