Glioneuronal tumors PATZ1-fused: clinico-molecular and DNA methylation signatures for a variety of morphological and radiological profiles

Glioneuronal tumors PATZ1-fused: clinico-molecular and DNA methylation signatures for a variety of morphological and radiological profiles

Abstract The neuroepithelial tumor, PATZ1-fused (NET-PATZ1), has been recently isolated as a distinct methylation class by DNA-methylation profiling and is characterized by recurrent PATZ1 fusions, in association with the EWSR1 or MN1 genes and a chromosome 22 chromothripsis. The clinical phenotype...

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Main Authors: Arnault Tauziède-Espariat, Volodia Dangouloff-Ros, Philipp Sievers, Mathilde Duchesne, Aurore Siegfried, Yvan Nicaise, Nathalie Boddaert, Lauren Hasty, Alice Métais, Carine Ngo, François le Loarer, Corinne Bouvier, Alix Fontaine, Audrey Rousseau, Florent Marguet, Kévin Beccaria, Thomas Blauwblomme, Emmanuelle Uro-Coste, Pascale Varlet, On behalf of the RENOCLIP-LOC
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Glioneuronal tumor
EWSR1::PATZ1
MN1::PATZ1
DNA-methylation
Online Access:https://doi.org/10.1186/s40478-025-02037-5
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