Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood–brain barrier permeability in female CLP mice

Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood–brain barrier permeability in female CLP mice

Abstract Background Septic encephalopathy is frequent but its pathophysiology is enigmatic. We studied expression of neurotransmitters, inflammation and integrity of the blood–brain barrier (BBB) in several brain regions during abdominal sepsis. We compared mice with either lethal or surviving pheno...

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Main Authors: Fatemeh Azizian-Farsani, Katrin Weixelbaumer, Daniel Mascher, Andrea Klang, Sandra Högler, Nora Dinhopl, Barbara Bauder, Herbert Weissenböck, Alexander Tichy, Peter Schmidt, Hermann Mascher, Marcin F. Osuchowski
Format: Article
Language:English
Published: SpringerOpen 2024-11-01
Series:Intensive Care Medicine Experimental
Subjects:
Abdominal sepsis
Brain amines
Cytokines
Phenotyping
Outcome prediction
Online Access:https://doi.org/10.1186/s40635-024-00688-7
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