African swine fever clinical scoring system
African swine fever (ASF) is a hemorrhagic viral disease that brings serious implications for animal health and economy due to high mortality rate, quarantine measures and restrictions on international trade in pig products. Only domestic and wild species of the Suidae family of all breeds and ages...
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Da Vinci Media
2024-12-01
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| Series: | Ветеринария сегодня |
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| Online Access: | https://veterinary.arriah.ru/jour/article/view/868 |
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| author | M. E. Vlasov V. M. Balyshev A. D. Sereda |
| author_facet | M. E. Vlasov V. M. Balyshev A. D. Sereda |
| author_sort | M. E. Vlasov |
| collection | DOAJ |
| description | African swine fever (ASF) is a hemorrhagic viral disease that brings serious implications for animal health and economy due to high mortality rate, quarantine measures and restrictions on international trade in pig products. Only domestic and wild species of the Suidae family of all breeds and ages are susceptible to infection with ASF virus. To date, no safe and effective ASF vaccines have been developed, but in recent years some progress has been made in development of ASF modified live virus first-generation vaccine candidates, which have been used only in some countries of Southeast Asia. The expansion of their use is hindered, among other things, due to the lack of international and state recommendations (requirements) for the evaluation of purity, activity, safety and effectiveness of ASF vaccine candidates. Clinical signs of the disease are one of the main indicators of safety and effectiveness of ASF modified live virus vaccine candidates. The purpose of this work was to develop a clinical symptom-based scoring system to be used for characterizing of newly recovered ASFV isolates causing various forms of the disease, as well as for the determination of safety and effectiveness of ASF modified live virus vaccine candidates. It is proposed to take into account 7 major clinical manifestations: an increase in body temperature, reduced liveliness, loss of appetite, skin lesions, joint swelling, laboured breathing, neurological disorders, each scored from 0 to 3 or 4. The study of twelve ASFV strains of various virulence revealed that acute and subacute ASF produce the maximum clinical scores ranged from 13 to 22, chronic form gives 6–18 points, subclinical form is scored 0–8. |
| format | Article |
| id | doaj-art-71e5a4eac452400c8a59ce174fc92214 |
| institution | Kabale University |
| issn | 2304-196X 2658-6959 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Da Vinci Media |
| record_format | Article |
| series | Ветеринария сегодня |
| spelling | doaj-art-71e5a4eac452400c8a59ce174fc922142025-02-06T09:52:10ZengDa Vinci MediaВетеринария сегодня2304-196X2658-69592024-12-0113434435110.29326/2304-196X-2024-13-4-344-351693African swine fever clinical scoring systemM. E. Vlasov0V. M. Balyshev1A. D. Sereda2Federal Research Center for Virology and MicrobiologyFederal Research Center for Virology and MicrobiologyFederal Research Center for Virology and MicrobiologyAfrican swine fever (ASF) is a hemorrhagic viral disease that brings serious implications for animal health and economy due to high mortality rate, quarantine measures and restrictions on international trade in pig products. Only domestic and wild species of the Suidae family of all breeds and ages are susceptible to infection with ASF virus. To date, no safe and effective ASF vaccines have been developed, but in recent years some progress has been made in development of ASF modified live virus first-generation vaccine candidates, which have been used only in some countries of Southeast Asia. The expansion of their use is hindered, among other things, due to the lack of international and state recommendations (requirements) for the evaluation of purity, activity, safety and effectiveness of ASF vaccine candidates. Clinical signs of the disease are one of the main indicators of safety and effectiveness of ASF modified live virus vaccine candidates. The purpose of this work was to develop a clinical symptom-based scoring system to be used for characterizing of newly recovered ASFV isolates causing various forms of the disease, as well as for the determination of safety and effectiveness of ASF modified live virus vaccine candidates. It is proposed to take into account 7 major clinical manifestations: an increase in body temperature, reduced liveliness, loss of appetite, skin lesions, joint swelling, laboured breathing, neurological disorders, each scored from 0 to 3 or 4. The study of twelve ASFV strains of various virulence revealed that acute and subacute ASF produce the maximum clinical scores ranged from 13 to 22, chronic form gives 6–18 points, subclinical form is scored 0–8.https://veterinary.arriah.ru/jour/article/view/868african swine feverclinical signsvaccine candidates |
| spellingShingle | M. E. Vlasov V. M. Balyshev A. D. Sereda African swine fever clinical scoring system Ветеринария сегодня african swine fever clinical signs vaccine candidates |
| title | African swine fever clinical scoring system |
| title_full | African swine fever clinical scoring system |
| title_fullStr | African swine fever clinical scoring system |
| title_full_unstemmed | African swine fever clinical scoring system |
| title_short | African swine fever clinical scoring system |
| title_sort | african swine fever clinical scoring system |
| topic | african swine fever clinical signs vaccine candidates |
| url | https://veterinary.arriah.ru/jour/article/view/868 |
| work_keys_str_mv | AT mevlasov africanswinefeverclinicalscoringsystem AT vmbalyshev africanswinefeverclinicalscoringsystem AT adsereda africanswinefeverclinicalscoringsystem |