Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement
Early-stage chronic lymphocytic leukemia (CLL) with neurologic involvement is a rare condition and should require a careful follow-up. Although no standard protocol exists for this condition, intrathecal chemotherapy, combined with systemic chemoimmunotherapy, has been used previously. This case des...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/7817918 |
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| _version_ | 1832558322358681600 |
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| author | Filipa Mousinho Tatiana Mendes Paula Sousa e Santos Maria João Acosta José Pereira Maria Arroz Cândido Silva Ana Paula Azevedo Rita Oliveira Martinha Chorão Fernando Lima |
| author_facet | Filipa Mousinho Tatiana Mendes Paula Sousa e Santos Maria João Acosta José Pereira Maria Arroz Cândido Silva Ana Paula Azevedo Rita Oliveira Martinha Chorão Fernando Lima |
| author_sort | Filipa Mousinho |
| collection | DOAJ |
| description | Early-stage chronic lymphocytic leukemia (CLL) with neurologic involvement is a rare condition and should require a careful follow-up. Although no standard protocol exists for this condition, intrathecal chemotherapy, combined with systemic chemoimmunotherapy, has been used previously. This case describes the treatment of a patient with CLL and symptomatic compromise of the central nervous system. Our results suggest that a combination of chemotherapy, radiotherapy, and ibrutinib, administered sequentially over a 2-year period, led to a near-complete resolution of the cerebral spinal fluid neoplastic infiltration. Importantly, this response has been maintained with ibrutinib monotherapy for more than 12 months. |
| format | Article |
| id | doaj-art-71e2003345bb4e31a9e0c7033de02cdf |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-71e2003345bb4e31a9e0c7033de02cdf2025-02-03T01:32:39ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/78179187817918Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System InvolvementFilipa Mousinho0Tatiana Mendes1Paula Sousa e Santos2Maria João Acosta3José Pereira4Maria Arroz5Cândido Silva6Ana Paula Azevedo7Rita Oliveira8Martinha Chorão9Fernando Lima10Clinical Hematology Department, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Hematology Department, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Hematology Department, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Pathology Department, Flow Cytometry Laboratory, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Pathology Department, Flow Cytometry Laboratory, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Pathology Department, Flow Cytometry Laboratory, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Pathology Department, Hematology Laboratory, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Pathology Department, Hematology Laboratory, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalPathology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalPathology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalClinical Hematology Department, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, PortugalEarly-stage chronic lymphocytic leukemia (CLL) with neurologic involvement is a rare condition and should require a careful follow-up. Although no standard protocol exists for this condition, intrathecal chemotherapy, combined with systemic chemoimmunotherapy, has been used previously. This case describes the treatment of a patient with CLL and symptomatic compromise of the central nervous system. Our results suggest that a combination of chemotherapy, radiotherapy, and ibrutinib, administered sequentially over a 2-year period, led to a near-complete resolution of the cerebral spinal fluid neoplastic infiltration. Importantly, this response has been maintained with ibrutinib monotherapy for more than 12 months.http://dx.doi.org/10.1155/2018/7817918 |
| spellingShingle | Filipa Mousinho Tatiana Mendes Paula Sousa e Santos Maria João Acosta José Pereira Maria Arroz Cândido Silva Ana Paula Azevedo Rita Oliveira Martinha Chorão Fernando Lima Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement Case Reports in Hematology |
| title | Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement |
| title_full | Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement |
| title_fullStr | Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement |
| title_full_unstemmed | Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement |
| title_short | Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement |
| title_sort | treatment sequencing in a chronic lymphocytic leukemia patient with central nervous system involvement |
| url | http://dx.doi.org/10.1155/2018/7817918 |
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