Acromegaloid Facial Appearance: Case Report and Literature Review
Pseudoacromegaly is characterized by an acromegalic appearance without any abnormality of growth hormone function. It may be caused by several congenital and acquired conditions. One such condition is the acromegaloid facial appearance (AFA) syndrome. This condition has been described in approximate...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/970396 |
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| author | Adline Ghazi Shikha Khosla Kenneth Becker |
| author_facet | Adline Ghazi Shikha Khosla Kenneth Becker |
| author_sort | Adline Ghazi |
| collection | DOAJ |
| description | Pseudoacromegaly is characterized by an acromegalic appearance without any abnormality of growth hormone function. It may be caused by several congenital and acquired conditions. One such condition is the acromegaloid facial appearance (AFA) syndrome. This condition has been described in approximately eight cases/families. It encompasses a spectrum of acromegaloid physical findings, normal growth hormone (GH) and insulin-like growth factor one (IGF-1) levels, and variable mode of inheritance. The most common physical findings are coarse facies, bulbous nose, and thickened lips. We present a case and a review of the literature on this illness. The patient is a 57-year-old woman who was referred to the endocrinology division for evaluation of suspected acromegaly. She had an acromegaloid appearance since birth as well as a terminal hypertrichosis. Her endocrine laboratory evaluation and chromosomal analyses were normal. AFA needs to be considered when evaluating any patient with pseudoacromegaly. Additional cases/families need to be identified in order to better understand the clinical spectrum, clinical implications, and mode of inheritance of AFA. |
| format | Article |
| id | doaj-art-71de5e7fdde24bf3a4397672c32379f2 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-71de5e7fdde24bf3a4397672c32379f22025-02-03T05:57:32ZengWileyCase Reports in Endocrinology2090-65012090-651X2013-01-01201310.1155/2013/970396970396Acromegaloid Facial Appearance: Case Report and Literature ReviewAdline Ghazi0Shikha Khosla1Kenneth Becker2Diabetes Care Program, Medstar Good Samaritan Hospital, 5601 Loch Raven Blvd, Baltimore, MD 21239, USADivision of Endocrinology, Washington DC Veterans Affairs Medical Center (DCVAMC), George Washington University, Washington, DC, USADivision of Endocrinology, Washington DC Veterans Affairs Medical Center (DCVAMC), George Washington University, Washington, DC, USAPseudoacromegaly is characterized by an acromegalic appearance without any abnormality of growth hormone function. It may be caused by several congenital and acquired conditions. One such condition is the acromegaloid facial appearance (AFA) syndrome. This condition has been described in approximately eight cases/families. It encompasses a spectrum of acromegaloid physical findings, normal growth hormone (GH) and insulin-like growth factor one (IGF-1) levels, and variable mode of inheritance. The most common physical findings are coarse facies, bulbous nose, and thickened lips. We present a case and a review of the literature on this illness. The patient is a 57-year-old woman who was referred to the endocrinology division for evaluation of suspected acromegaly. She had an acromegaloid appearance since birth as well as a terminal hypertrichosis. Her endocrine laboratory evaluation and chromosomal analyses were normal. AFA needs to be considered when evaluating any patient with pseudoacromegaly. Additional cases/families need to be identified in order to better understand the clinical spectrum, clinical implications, and mode of inheritance of AFA.http://dx.doi.org/10.1155/2013/970396 |
| spellingShingle | Adline Ghazi Shikha Khosla Kenneth Becker Acromegaloid Facial Appearance: Case Report and Literature Review Case Reports in Endocrinology |
| title | Acromegaloid Facial Appearance: Case Report and Literature Review |
| title_full | Acromegaloid Facial Appearance: Case Report and Literature Review |
| title_fullStr | Acromegaloid Facial Appearance: Case Report and Literature Review |
| title_full_unstemmed | Acromegaloid Facial Appearance: Case Report and Literature Review |
| title_short | Acromegaloid Facial Appearance: Case Report and Literature Review |
| title_sort | acromegaloid facial appearance case report and literature review |
| url | http://dx.doi.org/10.1155/2013/970396 |
| work_keys_str_mv | AT adlineghazi acromegaloidfacialappearancecasereportandliteraturereview AT shikhakhosla acromegaloidfacialappearancecasereportandliteraturereview AT kennethbecker acromegaloidfacialappearancecasereportandliteraturereview |