Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes
IntroductionProstate cancer remains a prevalent malignancy among men, often necessitating innovative therapeutic strategies for effective management of recurrent cases. This article examines the critical role of a biodegradable hydrogel spacer, which creates a temporary interspace between the prosta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1494304/full |
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| author | Amina Lazrek Sebastiano Finocchi Ghersi Adeline Petre Sarah Houabes Anne-Agathe Serre Frederic Gassa Magali Sandt Cecile Laude Camille Roukoz Salvatore Cozzi |
| author_facet | Amina Lazrek Sebastiano Finocchi Ghersi Adeline Petre Sarah Houabes Anne-Agathe Serre Frederic Gassa Magali Sandt Cecile Laude Camille Roukoz Salvatore Cozzi |
| author_sort | Amina Lazrek |
| collection | DOAJ |
| description | IntroductionProstate cancer remains a prevalent malignancy among men, often necessitating innovative therapeutic strategies for effective management of recurrent cases. This article examines the critical role of a biodegradable hydrogel spacer, which creates a temporary interspace between the prostate and the rectum, thus reducing radiation exposure to healthy tissues.Case descriptionWe present a case of a man with a history of intermediate-risk prostate adenocarcinoma initially treated with external beam radiotherapy in 2015. Despite initial remission, the patient experienced a rise in prostate-specific antigen (PSA) levels indicative of local recurrence in 2022. Salvage treatment with iodine-125 brachytherapy, preceded by the placement of a rectal spacer in January 2024, resulted in a significant reduction of PSA levels. The patient remains asymptomatic with no urinary or gastrointestinal complications 6 months after the salvage treatment.DiscussionThis case illustrates the complexities in managing recurrent prostate cancer and the evolving role of reirradiation strategies. Salvage iodine-125 brachytherapy with the placement of a rectal spacer provided precise radiation delivery while minimizing rectal toxicities. The significant biochemical response observed underscores the efficacy of this approach in controlling disease progression. The rectal spacer enhances treatment safety by reducing radiation exposure to adjacent tissues, highlighting its importance in reirradiation protocols. This case contributes to the growing evidence supporting the rectal spacer’s role in enhancing the safety and efficacy of salvage brachytherapy for recurrent prostate cancer.ConclusionsOur experience advocates for the integration of a hydrogel rectal spacer as a valuable tool in prostate cancer reirradiation protocols, offering a strategic approach to optimize treatment safety by minimizing rectal toxicity. |
| format | Article |
| id | doaj-art-71d56b625a9f4617901e7c81e8ac165e |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-71d56b625a9f4617901e7c81e8ac165e2025-01-30T05:10:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.14943041494304Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notesAmina Lazrek0Sebastiano Finocchi Ghersi1Adeline Petre2Sarah Houabes3Anne-Agathe Serre4Frederic Gassa5Magali Sandt6Cecile Laude7Camille Roukoz8Salvatore Cozzi9Radiation Oncology Unit, International University Hospital Cheikh Zaid, Rabat, MoroccoRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, ItalyRadiation Oncology Department, Centre Leon Berard, Lyon, FranceRadiation Oncology Unit, Portes de Provence Hospital Groupe, Montelimar, FranceRadiation Oncology Department, Centre Leon Berard, Lyon, FranceRadiation Oncology Department, Centre Leon Berard, Lyon, FranceRadiation Oncology Department, Centre Leon Berard, Lyon, FranceRadiation Oncology Department, Centre Leon Berard, Lyon, FranceRadiation Oncology Department, Centre Leon Berard, Lyon, FranceRadiation Oncology Department, Centre Leon Berard, Lyon, FranceIntroductionProstate cancer remains a prevalent malignancy among men, often necessitating innovative therapeutic strategies for effective management of recurrent cases. This article examines the critical role of a biodegradable hydrogel spacer, which creates a temporary interspace between the prostate and the rectum, thus reducing radiation exposure to healthy tissues.Case descriptionWe present a case of a man with a history of intermediate-risk prostate adenocarcinoma initially treated with external beam radiotherapy in 2015. Despite initial remission, the patient experienced a rise in prostate-specific antigen (PSA) levels indicative of local recurrence in 2022. Salvage treatment with iodine-125 brachytherapy, preceded by the placement of a rectal spacer in January 2024, resulted in a significant reduction of PSA levels. The patient remains asymptomatic with no urinary or gastrointestinal complications 6 months after the salvage treatment.DiscussionThis case illustrates the complexities in managing recurrent prostate cancer and the evolving role of reirradiation strategies. Salvage iodine-125 brachytherapy with the placement of a rectal spacer provided precise radiation delivery while minimizing rectal toxicities. The significant biochemical response observed underscores the efficacy of this approach in controlling disease progression. The rectal spacer enhances treatment safety by reducing radiation exposure to adjacent tissues, highlighting its importance in reirradiation protocols. This case contributes to the growing evidence supporting the rectal spacer’s role in enhancing the safety and efficacy of salvage brachytherapy for recurrent prostate cancer.ConclusionsOur experience advocates for the integration of a hydrogel rectal spacer as a valuable tool in prostate cancer reirradiation protocols, offering a strategic approach to optimize treatment safety by minimizing rectal toxicity.https://www.frontiersin.org/articles/10.3389/fonc.2025.1494304/fullrectal spacerhydrogel spacerprostate reirradiationprostate cancerbrachytherapy |
| spellingShingle | Amina Lazrek Sebastiano Finocchi Ghersi Adeline Petre Sarah Houabes Anne-Agathe Serre Frederic Gassa Magali Sandt Cecile Laude Camille Roukoz Salvatore Cozzi Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes Frontiers in Oncology rectal spacer hydrogel spacer prostate reirradiation prostate cancer brachytherapy |
| title | Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes |
| title_full | Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes |
| title_fullStr | Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes |
| title_full_unstemmed | Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes |
| title_short | Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes |
| title_sort | case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via ldr brachytherapy applications and technical notes |
| topic | rectal spacer hydrogel spacer prostate reirradiation prostate cancer brachytherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1494304/full |
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