Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey
Aim. We assessed the bone mineral density and related parameters in nine adults, thirty-eight pubertal, prepubertal totally forty-seven patients with thalassemia major living in Antalya, Turkey. Materials and Methods. We measured height and pubertal staging in last five years by six-month intervals....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/573298 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548062929616896 |
|---|---|
| author | Ibrahim Aslan Duran Canatan Nihal Balta Gulizar Kacar Cengaver Dorak Ahmet Ozsancak Nurgul Oguz Ruya Cosan |
| author_facet | Ibrahim Aslan Duran Canatan Nihal Balta Gulizar Kacar Cengaver Dorak Ahmet Ozsancak Nurgul Oguz Ruya Cosan |
| author_sort | Ibrahim Aslan |
| collection | DOAJ |
| description | Aim. We assessed the bone mineral density and related parameters in nine adults, thirty-eight pubertal, prepubertal totally forty-seven patients with thalassemia major living in Antalya, Turkey. Materials and Methods. We measured height and pubertal staging in last five years by six-month intervals. Average ferritin and hemoglobin concentrations were calculated for last three years. The levels of hydroxyproline, calcium, phosphorus, and creatinine were measured in 24 h urine, and those of parathormone, IGF 1, osteocalcine, alkaline phosphatase, calcium, ionized calcium, magnesium, phosphorus, creatine, blood glucose, thyroid stimulating hormone, alanine transaminase, and aspartate transaminase were determined in serum, and also the bone mineral density was measured. Results. The average L1–L4 bone mass density was 27.1±10.1 g cm−2; the average bone mineral content was 0.65 ± 0.11 g. of the patients with a Z-score under 2.5. A moderate relationship was found between the bone mass density age and height. Subjects in low pubertal staging and short stature
(<3% percentile) have significantly lower bone mass densities P<0.001. Conclusion.
he prevalence of osteoporosis is high in patients with thalassemia major, possibly related to delayed puberty. |
| format | Article |
| id | doaj-art-71b264ee3f5a4056bf94df50726a7bab |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-71b264ee3f5a4056bf94df50726a7bab2025-02-03T06:42:23ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/573298573298Bone Mineral Density in Thalassemia Major Patients from Antalya, TurkeyIbrahim Aslan0Duran Canatan1Nihal Balta2Gulizar Kacar3Cengaver Dorak4Ahmet Ozsancak5Nurgul Oguz6Ruya Cosan7Department of Endocrinology and Metabolism, Antalya Education and Research Hospital, 07100 Antalya, TurkeyHemoglobinopathy Diagnosis Center, Mediterranean Blood Diseases Foundation and Thalassemia Federation of Turkey, Antalya, TurkeyAntalya State Hospital, 07100 Antalya, TurkeyDepartment of Nuclear Medicine, Antalya Education and Research Hospital, 07100 Antalya, TurkeyAntalya State Hospital, 07100 Antalya, TurkeyAntalya State Hospital, 07100 Antalya, TurkeyAntalya State Hospital, 07100 Antalya, TurkeyAntalya State Hospital, 07100 Antalya, TurkeyAim. We assessed the bone mineral density and related parameters in nine adults, thirty-eight pubertal, prepubertal totally forty-seven patients with thalassemia major living in Antalya, Turkey. Materials and Methods. We measured height and pubertal staging in last five years by six-month intervals. Average ferritin and hemoglobin concentrations were calculated for last three years. The levels of hydroxyproline, calcium, phosphorus, and creatinine were measured in 24 h urine, and those of parathormone, IGF 1, osteocalcine, alkaline phosphatase, calcium, ionized calcium, magnesium, phosphorus, creatine, blood glucose, thyroid stimulating hormone, alanine transaminase, and aspartate transaminase were determined in serum, and also the bone mineral density was measured. Results. The average L1–L4 bone mass density was 27.1±10.1 g cm−2; the average bone mineral content was 0.65 ± 0.11 g. of the patients with a Z-score under 2.5. A moderate relationship was found between the bone mass density age and height. Subjects in low pubertal staging and short stature (<3% percentile) have significantly lower bone mass densities P<0.001. Conclusion. he prevalence of osteoporosis is high in patients with thalassemia major, possibly related to delayed puberty.http://dx.doi.org/10.1155/2012/573298 |
| spellingShingle | Ibrahim Aslan Duran Canatan Nihal Balta Gulizar Kacar Cengaver Dorak Ahmet Ozsancak Nurgul Oguz Ruya Cosan Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey International Journal of Endocrinology |
| title | Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey |
| title_full | Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey |
| title_fullStr | Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey |
| title_full_unstemmed | Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey |
| title_short | Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey |
| title_sort | bone mineral density in thalassemia major patients from antalya turkey |
| url | http://dx.doi.org/10.1155/2012/573298 |
| work_keys_str_mv | AT ibrahimaslan bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey AT durancanatan bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey AT nihalbalta bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey AT gulizarkacar bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey AT cengaverdorak bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey AT ahmetozsancak bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey AT nurguloguz bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey AT ruyacosan bonemineraldensityinthalassemiamajorpatientsfromantalyaturkey |