Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population
Purpose. To determine whether hypertriglyceridemic waist (HTGW) and high lipid accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus (T2DM), and to investigate the interactions of HTGW and LAP with other components of metabolic syndrome on the risk of T2DM. Methods. A total o...
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| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/9157430 |
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| author | Minrui Xu Mingtao Huang Deren Qiang Jianxin Gu Yong Li Yingzi Pan Xingjuan Yao Wenchao Xu Yuan Tao Yihong Zhou Hongxia Ma |
| author_facet | Minrui Xu Mingtao Huang Deren Qiang Jianxin Gu Yong Li Yingzi Pan Xingjuan Yao Wenchao Xu Yuan Tao Yihong Zhou Hongxia Ma |
| author_sort | Minrui Xu |
| collection | DOAJ |
| description | Purpose. To determine whether hypertriglyceridemic waist (HTGW) and high lipid accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus (T2DM), and to investigate the interactions of HTGW and LAP with other components of metabolic syndrome on the risk of T2DM. Methods. A total of 15,717 eligible participants without baseline T2DM and aged 35 and over were included from a Chinese rural cohort. Cox proportional hazards regression models were used to estimate the association of HTGW and LAP with the incidence of T2DM, and the restricted cubic spline model was used to evaluate the dose-response association. Results. Overall, 867 new T2DM cases were diagnosed after 7.77 years of follow-up. Participants with HTGW had a higher hazard ratio for T2DM (hazard ratio (HR): 6.249, 95% confidence interval (CI): 5.199-7.511) after adjustment for potential confounders. The risk of incident T2DM was increased with quartiles 3 and 4 versus quartile 1 of LAP, and the adjusted HRs (95% CIs) were 2.903 (2.226-3.784) and 6.298 (4.911-8.077), respectively. There were additive interactions of HTGW (synergy index (SI): 1.678, 95% CI: 1.358-2.072) and high LAP (SI: 1.701, 95% CI: 1.406-2.059) with increased fasting plasma glucose (FPG) on the risk of T2DM. Additionally, a nonlinear (P nonlinear < 0.001) dose-response association was found between LAP and T2DM. Conclusion. The subjects with HTGW and high LAP were at high risk of developing T2DM, and the association between LAP and the risk of T2DM may be nonlinear. Our study further demonstrates additive interactions of HTGW and high LAP with increased FPG on the risk of T2DM. |
| format | Article |
| id | doaj-art-71b18e17788c42738aca3341ed90fc18 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-71b18e17788c42738aca3341ed90fc182025-02-03T06:43:52ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/91574309157430Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese PopulationMinrui Xu0Mingtao Huang1Deren Qiang2Jianxin Gu3Yong Li4Yingzi Pan5Xingjuan Yao6Wenchao Xu7Yuan Tao8Yihong Zhou9Hongxia Ma10Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, ChinaWujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaWujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaWujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaWujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaChangzhou Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaChangzhou Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaDepartment of Medical Affairs, The Third Affiliated Hospital of Soochow University, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaWujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, ChinaDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, ChinaPurpose. To determine whether hypertriglyceridemic waist (HTGW) and high lipid accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus (T2DM), and to investigate the interactions of HTGW and LAP with other components of metabolic syndrome on the risk of T2DM. Methods. A total of 15,717 eligible participants without baseline T2DM and aged 35 and over were included from a Chinese rural cohort. Cox proportional hazards regression models were used to estimate the association of HTGW and LAP with the incidence of T2DM, and the restricted cubic spline model was used to evaluate the dose-response association. Results. Overall, 867 new T2DM cases were diagnosed after 7.77 years of follow-up. Participants with HTGW had a higher hazard ratio for T2DM (hazard ratio (HR): 6.249, 95% confidence interval (CI): 5.199-7.511) after adjustment for potential confounders. The risk of incident T2DM was increased with quartiles 3 and 4 versus quartile 1 of LAP, and the adjusted HRs (95% CIs) were 2.903 (2.226-3.784) and 6.298 (4.911-8.077), respectively. There were additive interactions of HTGW (synergy index (SI): 1.678, 95% CI: 1.358-2.072) and high LAP (SI: 1.701, 95% CI: 1.406-2.059) with increased fasting plasma glucose (FPG) on the risk of T2DM. Additionally, a nonlinear (P nonlinear < 0.001) dose-response association was found between LAP and T2DM. Conclusion. The subjects with HTGW and high LAP were at high risk of developing T2DM, and the association between LAP and the risk of T2DM may be nonlinear. Our study further demonstrates additive interactions of HTGW and high LAP with increased FPG on the risk of T2DM.http://dx.doi.org/10.1155/2020/9157430 |
| spellingShingle | Minrui Xu Mingtao Huang Deren Qiang Jianxin Gu Yong Li Yingzi Pan Xingjuan Yao Wenchao Xu Yuan Tao Yihong Zhou Hongxia Ma Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population Journal of Diabetes Research |
| title | Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population |
| title_full | Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population |
| title_fullStr | Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population |
| title_full_unstemmed | Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population |
| title_short | Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population |
| title_sort | hypertriglyceridemic waist phenotype and lipid accumulation product two comprehensive obese indicators of waist circumference and triglyceride to predict type 2 diabetes mellitus in chinese population |
| url | http://dx.doi.org/10.1155/2020/9157430 |
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