Mechanisms of blaIMP-4 dissemination across diverse carbapenem-resistant clinical isolates

Mechanisms of blaIMP-4 dissemination across diverse carbapenem-resistant clinical isolates

ABSTRACT: Objective: The IMP-4 carbapenemase is an endemic cause of carbapenem resistance in the Asia-Pacific region. Our aim was to determine the dissemination mechanism of the blaIMP-4 gene. Methods: Twelve representative Australian IMP-4 clinical isolates from The Alfred Hospital (Victoria, Aust...

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Main Authors: Ying Fu, Faye C. Morris, Stephanie C. Pereira, Xenia Kostoulias, Yan Jiang, Callum Vidor, Galain Williams, Yogi Srikhanta, Nenad Macesic, Yunsong Yu, Dena Lyras, Anton Y. Peleg
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
BlaIMP-4
Species diversity
Plasmid incompatibility
Homologous recombination
IS-based resistance gene cassettes
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716525000086
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