Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomics
The angiotensin-converting enzyme (ACE) inhibitory peptide NCW derived from Mizuhopecten yessoensis has been demonstrated to have significant in vivo anti-hypertensive effects, however, its anti-hypertensive mechanism is still not fully clarified. This study established a UPLC-Q-TRAP-MS/MS-based wid...
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001556 |
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| author | Wenjun Xue Wenzhu Zhao Sijia Wu Zhipeng Yu |
| author_facet | Wenjun Xue Wenzhu Zhao Sijia Wu Zhipeng Yu |
| author_sort | Wenjun Xue |
| collection | DOAJ |
| description | The angiotensin-converting enzyme (ACE) inhibitory peptide NCW derived from Mizuhopecten yessoensis has been demonstrated to have significant in vivo anti-hypertensive effects, however, its anti-hypertensive mechanism is still not fully clarified. This study established a UPLC-Q-TRAP-MS/MS-based widely targeted kidney metabolomics approach to explore the changes of kidney metabolic profiles and to clarify the anti-hypertensive mechanism of peptide NCW in spontaneously hypertensive rats (SHRs). Multivariate statistical analysis indicated that the kidney metabolic profiles were clearly separated between the SHR-NCW and SHR-Untreated groups. A total of 85 metabolites were differentially regulated, and 16 metabolites were identified as potential kidney biomarkers, e.g., 3-hydroxybutyrate, malonic acid, deoxycytidine, and L-aspartic acid. The peptide NCW might regulate kidney metabolic disorder of SHRs to alleviate hypertension by suppressing inflammation and improving nitric oxide production under the regulation of linoleic acid metabolism, folate related pathways, synthesis and degradation of ketone bodies, pyrimidine metabolism, β-alanine metabolism, and retinal metabolism. |
| format | Article |
| id | doaj-art-71a2c512739640cd8fb551be7413f2ab |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-71a2c512739640cd8fb551be7413f2ab2025-02-03T04:09:17ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131472481Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomicsWenjun Xue0Wenzhu Zhao1Sijia Wu2Zhipeng Yu3School of Food Science and Engineering, Hainan University, Haikou 570228, China; College of Food Science and Engineering, Bohai University, Jinzhou 121013, ChinaSchool of Food Science and Engineering, Hainan University, Haikou 570228, ChinaLab of Nutrition and Functional Food, Jilin University, Changchun 130062, ChinaSchool of Food Science and Engineering, Hainan University, Haikou 570228, China; Corresponding author at: School of Food Science and Engineering, Hainan University, Haikou 570228, China.The angiotensin-converting enzyme (ACE) inhibitory peptide NCW derived from Mizuhopecten yessoensis has been demonstrated to have significant in vivo anti-hypertensive effects, however, its anti-hypertensive mechanism is still not fully clarified. This study established a UPLC-Q-TRAP-MS/MS-based widely targeted kidney metabolomics approach to explore the changes of kidney metabolic profiles and to clarify the anti-hypertensive mechanism of peptide NCW in spontaneously hypertensive rats (SHRs). Multivariate statistical analysis indicated that the kidney metabolic profiles were clearly separated between the SHR-NCW and SHR-Untreated groups. A total of 85 metabolites were differentially regulated, and 16 metabolites were identified as potential kidney biomarkers, e.g., 3-hydroxybutyrate, malonic acid, deoxycytidine, and L-aspartic acid. The peptide NCW might regulate kidney metabolic disorder of SHRs to alleviate hypertension by suppressing inflammation and improving nitric oxide production under the regulation of linoleic acid metabolism, folate related pathways, synthesis and degradation of ketone bodies, pyrimidine metabolism, β-alanine metabolism, and retinal metabolism.http://www.sciencedirect.com/science/article/pii/S2213453023001556ACE inhibitory peptideKidneyMechanismMetabolomicsSpontaneously hypertensive rats |
| spellingShingle | Wenjun Xue Wenzhu Zhao Sijia Wu Zhipeng Yu Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomics Food Science and Human Wellness ACE inhibitory peptide Kidney Mechanism Metabolomics Spontaneously hypertensive rats |
| title | Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomics |
| title_full | Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomics |
| title_fullStr | Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomics |
| title_full_unstemmed | Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomics |
| title_short | Underlying anti-hypertensive mechanism of the Mizuhopecten yessoensis derived peptide NCW in spontaneously hypertensive rats via widely targeted kidney metabolomics |
| title_sort | underlying anti hypertensive mechanism of the mizuhopecten yessoensis derived peptide ncw in spontaneously hypertensive rats via widely targeted kidney metabolomics |
| topic | ACE inhibitory peptide Kidney Mechanism Metabolomics Spontaneously hypertensive rats |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001556 |
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