Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, improving outcomes for many patients. However, toxicities termed immune-related adverse events (irAEs) are limitations of these revolutionary treatments. These irAEs may resolve with treatment or ICI cessation (acute) or persist...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-07-01
|
| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/12/7/e008591.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568984783814656 |
|---|---|
| author | Douglas B Johnson Kylie Fletcher |
| author_facet | Douglas B Johnson Kylie Fletcher |
| author_sort | Douglas B Johnson |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, improving outcomes for many patients. However, toxicities termed immune-related adverse events (irAEs) are limitations of these revolutionary treatments. These irAEs may resolve with treatment or ICI cessation (acute) or persist many months beyond therapy cessation (chronic). Acute irAEs were the first to be recognized and are thus more well studied. However, chronic irAEs have been highlighted in recent years and are becoming a topic of more intensive investigation. These chronic irAEs have been noted to affect many different organ systems, including endocrine, rheumatologic, gastrointestinal, dermatologic, neurologic, and cardiovascular systems. In this review, we discuss current knowledge surrounding the frequency, time course, and risk factors associated with chronic irAEs affecting various organ systems, treatment approaches, and future directions. |
| format | Article |
| id | doaj-art-71902b4475a548f1b06b7a09efc88722 |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-71902b4475a548f1b06b7a09efc887222025-02-02T23:40:08ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262024-07-0112710.1136/jitc-2023-008591Chronic immune-related adverse events arising from immune checkpoint inhibitors: an updateDouglas B Johnson0Kylie Fletcher11Vanderbilt University School of Medicine, Nashville, TN, USA1 Vanderbilt University School of Medicine, Nashville, Tennessee, USAImmune checkpoint inhibitors (ICIs) have transformed cancer treatment, improving outcomes for many patients. However, toxicities termed immune-related adverse events (irAEs) are limitations of these revolutionary treatments. These irAEs may resolve with treatment or ICI cessation (acute) or persist many months beyond therapy cessation (chronic). Acute irAEs were the first to be recognized and are thus more well studied. However, chronic irAEs have been highlighted in recent years and are becoming a topic of more intensive investigation. These chronic irAEs have been noted to affect many different organ systems, including endocrine, rheumatologic, gastrointestinal, dermatologic, neurologic, and cardiovascular systems. In this review, we discuss current knowledge surrounding the frequency, time course, and risk factors associated with chronic irAEs affecting various organ systems, treatment approaches, and future directions.https://jitc.bmj.com/content/12/7/e008591.full |
| spellingShingle | Douglas B Johnson Kylie Fletcher Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update Journal for ImmunoTherapy of Cancer |
| title | Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update |
| title_full | Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update |
| title_fullStr | Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update |
| title_full_unstemmed | Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update |
| title_short | Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update |
| title_sort | chronic immune related adverse events arising from immune checkpoint inhibitors an update |
| url | https://jitc.bmj.com/content/12/7/e008591.full |
| work_keys_str_mv | AT douglasbjohnson chronicimmunerelatedadverseeventsarisingfromimmunecheckpointinhibitorsanupdate AT kyliefletcher chronicimmunerelatedadverseeventsarisingfromimmunecheckpointinhibitorsanupdate |