Henoch-Schonlein Purpura—A Case Report and Review of the Literature
We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointesti...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/597648 |
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| author | Amit B. Sohagia Srinivas Guptha Gunturu Tommy R. Tong Hilary I. Hertan |
| author_facet | Amit B. Sohagia Srinivas Guptha Gunturu Tommy R. Tong Hilary I. Hertan |
| author_sort | Amit B. Sohagia |
| collection | DOAJ |
| description | We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage. |
| format | Article |
| id | doaj-art-718a401feb9e4e2cb4ec788ac0f65c7c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-718a401feb9e4e2cb4ec788ac0f65c7c2025-02-03T06:07:26ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/597648597648Henoch-Schonlein Purpura—A Case Report and Review of the LiteratureAmit B. Sohagia0Srinivas Guptha Gunturu1Tommy R. Tong2Hilary I. Hertan3Gastroenterology, Montefiore Medical Center, North Division, 600, E 233rd street, Bronx, NY 10466, USAInternal Medicine, Montefiore Medical Center, North Division, 600, E 233rd street, Bronx, NY 10466, USADepartment of Pathology, Montefiore Medical Center, North Division, 600, E 233rd street, Bronx, NY 10466, USAGastroenterology, Montefiore Medical Center, North Division, 600, E 233rd street, Bronx, NY 10466, USAWe describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage.http://dx.doi.org/10.1155/2010/597648 |
| spellingShingle | Amit B. Sohagia Srinivas Guptha Gunturu Tommy R. Tong Hilary I. Hertan Henoch-Schonlein Purpura—A Case Report and Review of the Literature Gastroenterology Research and Practice |
| title | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
| title_full | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
| title_fullStr | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
| title_full_unstemmed | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
| title_short | Henoch-Schonlein Purpura—A Case Report and Review of the Literature |
| title_sort | henoch schonlein purpura a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2010/597648 |
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