Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases
Chimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have been adopted to treat several kinds of malignanci...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/5727516 |
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| author | Yuehong Chen Jianhong Sun Huan Liu Geng Yin Qibing Xie |
| author_facet | Yuehong Chen Jianhong Sun Huan Liu Geng Yin Qibing Xie |
| author_sort | Yuehong Chen |
| collection | DOAJ |
| description | Chimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have been adopted to treat several kinds of malignancies. Autoimmune diseases (AIDs), a class of chronic disease conditions, can be broadly separated into autoantibody-mediated and T cell-mediated diseases. Treatments for AIDs are focused on restoring immune tolerance. However, current treatments have little effect on immune tolerance inverse; even the molecular target biologics like anti-TNFα inhibitors can only mildly restore immune balance. By using the idea of CAR-T cell treatment in tumors, CAR-T cell-derived immunotherapies, chimeric autoantibody receptor T (CAAR-T) cells, and CAR regulatory T (CAR-T) cells bring new hope of treatment choice for AIDs. |
| format | Article |
| id | doaj-art-718939a8d027464aae1c0bb9d959f9cf |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-718939a8d027464aae1c0bb9d959f9cf2025-02-03T01:30:15ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/57275165727516Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune DiseasesYuehong Chen0Jianhong Sun1Huan Liu2Geng Yin3Qibing Xie4Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan 610041, ChinaChimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have been adopted to treat several kinds of malignancies. Autoimmune diseases (AIDs), a class of chronic disease conditions, can be broadly separated into autoantibody-mediated and T cell-mediated diseases. Treatments for AIDs are focused on restoring immune tolerance. However, current treatments have little effect on immune tolerance inverse; even the molecular target biologics like anti-TNFα inhibitors can only mildly restore immune balance. By using the idea of CAR-T cell treatment in tumors, CAR-T cell-derived immunotherapies, chimeric autoantibody receptor T (CAAR-T) cells, and CAR regulatory T (CAR-T) cells bring new hope of treatment choice for AIDs.http://dx.doi.org/10.1155/2019/5727516 |
| spellingShingle | Yuehong Chen Jianhong Sun Huan Liu Geng Yin Qibing Xie Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases Journal of Immunology Research |
| title | Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases |
| title_full | Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases |
| title_fullStr | Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases |
| title_full_unstemmed | Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases |
| title_short | Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases |
| title_sort | immunotherapy deriving from car t cell treatment in autoimmune diseases |
| url | http://dx.doi.org/10.1155/2019/5727516 |
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