Investigation of the effıciency of pomegranate (punica granatum l.) peel extract on herpes simplex virus-1
<b>Aim: </b>This study, it was aimed to determine the antiviral activity of pomegranate peel (Punica granatum L.) extract on HSV-1 in vitro.<p> <b>Materials and Methods: </b>Before evaluating the antiviral efficacy, the cytotoxic activity of different concentrations of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2022-06-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1386 |
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| Summary: | <b>Aim: </b>This study, it was aimed to determine the antiviral activity of pomegranate
peel (Punica granatum L.) extract on HSV-1 in vitro.<p>
<b>Materials and Methods: </b>Before evaluating the antiviral efficacy, the cytotoxic
activity of different concentrations of pomegranate peel extract diluted with
distilled water in Vero cell culture was determined. It was determined that this
cell culture did not cause cytotoxicity at concentrations lower than 0.87 mg/
mL. Antiviral efficacy was determined by cytopathogenic effect (CPE) after the
MTT test and microscopic analysis.<p>
<b>Results: </b>It was determined that pomegranate peel extract had significant
antiviral activity against HSV-1 at concentrations between 0.87 mg/mL and
0.87x2-5mg/mL. This effect may have been achieved by preventing the virus
from entering the cell.<p>
<b>Conclusion:</b> It was thought that pomegranate peel extract has antiviral activity
against HSV-1 in vitro, and in line with the results obtained, in vivo trials
are needed to determine the antiviral activity of Punica granatum L. extract in
more detail. In addition, a precise determination of the effectiveness of Punica
granatum L. Extract against Herpes viruses and other viruses will contribute
to antiviral drug trials in the future. |
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| ISSN: | 1309-6958 2146-1953 |