Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)
We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein–Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Her direct an...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/4105653 |
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| author | Kenji M. Cunnion Lisa M. Feagin Michael F. Chicella Cortney L. Kaszowski Pamela S. Hair Jessica Price William C. Owen |
| author_facet | Kenji M. Cunnion Lisa M. Feagin Michael F. Chicella Cortney L. Kaszowski Pamela S. Hair Jessica Price William C. Owen |
| author_sort | Kenji M. Cunnion |
| collection | DOAJ |
| description | We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein–Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Her direct antiglobulin test was positive for IgG and C3. To confirm this was ceftriaxone-induced complement-mediated hemolysis, we adapted the complement hemolysis using human erythrocytes (CHUHE) assay by adding exogenous ceftriaxone to the patient’s serum which enhanced lysis of her erythrocytes. We confirmed that ceftriaxone initiated a classical complement pathway-mediated hemolysis by in vitro reversal with peptide inhibitor of complement C1 (PIC1). |
| format | Article |
| id | doaj-art-71712697d0ea4195ad3373573e59fce5 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-71712697d0ea4195ad3373573e59fce52025-02-03T00:59:49ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/41056534105653Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1)Kenji M. Cunnion0Lisa M. Feagin1Michael F. Chicella2Cortney L. Kaszowski3Pamela S. Hair4Jessica Price5William C. Owen6Department of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USADepartment of Pharmacy, Children’s Hospital of the King’s Daughters, 601 Children’s Lane, Norfolk, VA 23507, USADepartment of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USADepartment of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USADepartment of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USADepartment of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USADepartment of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USAWe report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein–Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Her direct antiglobulin test was positive for IgG and C3. To confirm this was ceftriaxone-induced complement-mediated hemolysis, we adapted the complement hemolysis using human erythrocytes (CHUHE) assay by adding exogenous ceftriaxone to the patient’s serum which enhanced lysis of her erythrocytes. We confirmed that ceftriaxone initiated a classical complement pathway-mediated hemolysis by in vitro reversal with peptide inhibitor of complement C1 (PIC1).http://dx.doi.org/10.1155/2019/4105653 |
| spellingShingle | Kenji M. Cunnion Lisa M. Feagin Michael F. Chicella Cortney L. Kaszowski Pamela S. Hair Jessica Price William C. Owen Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1) Case Reports in Hematology |
| title | Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1) |
| title_full | Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1) |
| title_fullStr | Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1) |
| title_full_unstemmed | Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1) |
| title_short | Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1) |
| title_sort | ceftriaxone induced immune hemolytic anemia in vitro reversal with peptide inhibitor of complement c1 pic1 |
| url | http://dx.doi.org/10.1155/2019/4105653 |
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