A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/1279525 |
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| author | Mathijs Willemsen Arne W. J. H. Dielis Iryna V. Samarska Ad Koster Arienne M. van Marion |
| author_facet | Mathijs Willemsen Arne W. J. H. Dielis Iryna V. Samarska Ad Koster Arienne M. van Marion |
| author_sort | Mathijs Willemsen |
| collection | DOAJ |
| description | Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations is common in AITL and the B-cell component may resemble Reed-Sternberg-like B-cells. Epstein-Barr virus is estimated to be present in 80–95% of AITL biopsies. Only a handful of EBV-negative AITL cases with EBV-negative RS-like B-cells have been reported over the last decade. We present a rare case of EBV-negative AITL with chylous ascites and chylothorax. Microscopic and immunohistochemical analysis revealed the presence of EBV-negative Reed-Sternberg-like B-cells in the tumor. |
| format | Article |
| id | doaj-art-716928853ce94314ac02a70103b18078 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-716928853ce94314ac02a70103b180782025-02-03T01:32:47ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/12795251279525A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and ChylothoraxMathijs Willemsen0Arne W. J. H. Dielis1Iryna V. Samarska2Ad Koster3Arienne M. van Marion4Department of Internal Medicine, VieCuri Medical Centre, 5912 BL Venlo, NetherlandsDepartment of Internal Medicine, VieCuri Medical Centre, 5912 BL Venlo, NetherlandsDepartment of Pathology, VieCuri Medical Centre, 5912 BL Venlo, NetherlandsDepartment of Internal Medicine, VieCuri Medical Centre, 5912 BL Venlo, NetherlandsDepartment of Pathology, VieCuri Medical Centre, 5912 BL Venlo, NetherlandsAngioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations is common in AITL and the B-cell component may resemble Reed-Sternberg-like B-cells. Epstein-Barr virus is estimated to be present in 80–95% of AITL biopsies. Only a handful of EBV-negative AITL cases with EBV-negative RS-like B-cells have been reported over the last decade. We present a rare case of EBV-negative AITL with chylous ascites and chylothorax. Microscopic and immunohistochemical analysis revealed the presence of EBV-negative Reed-Sternberg-like B-cells in the tumor.http://dx.doi.org/10.1155/2017/1279525 |
| spellingShingle | Mathijs Willemsen Arne W. J. H. Dielis Iryna V. Samarska Ad Koster Arienne M. van Marion A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax Case Reports in Hematology |
| title | A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax |
| title_full | A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax |
| title_fullStr | A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax |
| title_full_unstemmed | A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax |
| title_short | A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax |
| title_sort | rare case of angioimmunoblastic t cell lymphoma with epstein barr virus negative reed sternberg like b cells chylous ascites and chylothorax |
| url | http://dx.doi.org/10.1155/2017/1279525 |
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