Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation
Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/234391 |
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| _version_ | 1832560318604115968 |
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| author | Esin Oktay Özlem Yersal Nezih Meydan Mehmet Sağıroğlu Ömer Uyanık Sabri Barutca |
| author_facet | Esin Oktay Özlem Yersal Nezih Meydan Mehmet Sağıroğlu Ömer Uyanık Sabri Barutca |
| author_sort | Esin Oktay |
| collection | DOAJ |
| description | Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine. |
| format | Article |
| id | doaj-art-715e8daacfae4710be01f94c5b4b9b53 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-715e8daacfae4710be01f94c5b4b9b532025-02-03T01:27:53ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/234391234391Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain IrradiationEsin Oktay0Özlem Yersal1Nezih Meydan2Mehmet Sağıroğlu3Ömer Uyanık4Sabri Barutca5Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, TurkeyTrastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine.http://dx.doi.org/10.1155/2013/234391 |
| spellingShingle | Esin Oktay Özlem Yersal Nezih Meydan Mehmet Sağıroğlu Ömer Uyanık Sabri Barutca Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation Case Reports in Oncological Medicine |
| title | Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation |
| title_full | Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation |
| title_fullStr | Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation |
| title_full_unstemmed | Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation |
| title_short | Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation |
| title_sort | nearly complete response of brain metastases from her2 overexpressing breast cancer with lapatinib and capecitabine after whole brain irradiation |
| url | http://dx.doi.org/10.1155/2013/234391 |
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