Liver Transplantation for Hepatitis C and Alcoholic Liver Disease
End-stage liver disease due to hepatitis C (HCV) and cirrhosis from alcohol (ALD) are the commonest indications for liver transplantation in the western countries. Up to one third of HCV-infected transplant candidates have a history of significant alcohol intake...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2010/893893 |
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| author | Marco Carbone James Neuberger |
| author_facet | Marco Carbone James Neuberger |
| author_sort | Marco Carbone |
| collection | DOAJ |
| description | End-stage liver disease due to hepatitis C (HCV) and cirrhosis from alcohol (ALD) are the commonest indications for
liver transplantation in the western countries. Up to one third of HCV-infected transplant candidates have a history of
significant alcohol intake prior to transplantation. However, there are few data available about the possible interaction between alcohol
and HCV in the post-transplant setting. Patients with both HCV and alcohol are more likely to die on the waiting list than those with
ALD and HCV alone. However, after transplantation, non-risk adjusted graft and patient survival of patients with HCV + ALD are comparable to
those of patients with HCV cirrhosis or ALD cirrhosis alone. In the short and medium term HCV recurrence after transplant in patients with
HCV + ALD cirrhosis does not seem more aggressive than that in patients with HCV cirrhosis alone. A relapse in alcohol consumption in
patients with HCV + ALD cirrhosis does not have a major impact on graft survival. The evidence shows that, as is currently practiced,
HCV + ALD as an appropriate indication for liver transplantation. However, these data are based on retrospective analyses with relatively
short follow-up so the conclusions must be treated with caution. |
| format | Article |
| id | doaj-art-71508d3ad47142fb95e4282e8153506a |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-71508d3ad47142fb95e4282e8153506a2025-02-03T06:01:41ZengWileyJournal of Transplantation2090-00072090-00152010-01-01201010.1155/2010/893893893893Liver Transplantation for Hepatitis C and Alcoholic Liver DiseaseMarco Carbone0James Neuberger1Liver Unit, Queen Elizabeth Hospital, Birmingham B152TH, UKLiver Unit, Queen Elizabeth Hospital, Birmingham B152TH, UKEnd-stage liver disease due to hepatitis C (HCV) and cirrhosis from alcohol (ALD) are the commonest indications for liver transplantation in the western countries. Up to one third of HCV-infected transplant candidates have a history of significant alcohol intake prior to transplantation. However, there are few data available about the possible interaction between alcohol and HCV in the post-transplant setting. Patients with both HCV and alcohol are more likely to die on the waiting list than those with ALD and HCV alone. However, after transplantation, non-risk adjusted graft and patient survival of patients with HCV + ALD are comparable to those of patients with HCV cirrhosis or ALD cirrhosis alone. In the short and medium term HCV recurrence after transplant in patients with HCV + ALD cirrhosis does not seem more aggressive than that in patients with HCV cirrhosis alone. A relapse in alcohol consumption in patients with HCV + ALD cirrhosis does not have a major impact on graft survival. The evidence shows that, as is currently practiced, HCV + ALD as an appropriate indication for liver transplantation. However, these data are based on retrospective analyses with relatively short follow-up so the conclusions must be treated with caution.http://dx.doi.org/10.1155/2010/893893 |
| spellingShingle | Marco Carbone James Neuberger Liver Transplantation for Hepatitis C and Alcoholic Liver Disease Journal of Transplantation |
| title | Liver Transplantation for Hepatitis C and Alcoholic Liver Disease |
| title_full | Liver Transplantation for Hepatitis C and Alcoholic Liver Disease |
| title_fullStr | Liver Transplantation for Hepatitis C and Alcoholic Liver Disease |
| title_full_unstemmed | Liver Transplantation for Hepatitis C and Alcoholic Liver Disease |
| title_short | Liver Transplantation for Hepatitis C and Alcoholic Liver Disease |
| title_sort | liver transplantation for hepatitis c and alcoholic liver disease |
| url | http://dx.doi.org/10.1155/2010/893893 |
| work_keys_str_mv | AT marcocarbone livertransplantationforhepatitiscandalcoholicliverdisease AT jamesneuberger livertransplantationforhepatitiscandalcoholicliverdisease |