Liver Transplantation for Hepatitis C and Alcoholic Liver Disease
End-stage liver disease due to hepatitis C (HCV) and cirrhosis from alcohol (ALD) are the commonest indications for liver transplantation in the western countries. Up to one third of HCV-infected transplant candidates have a history of significant alcohol intake...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2010/893893 |
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| Summary: | End-stage liver disease due to hepatitis C (HCV) and cirrhosis from alcohol (ALD) are the commonest indications for
liver transplantation in the western countries. Up to one third of HCV-infected transplant candidates have a history of
significant alcohol intake prior to transplantation. However, there are few data available about the possible interaction between alcohol
and HCV in the post-transplant setting. Patients with both HCV and alcohol are more likely to die on the waiting list than those with
ALD and HCV alone. However, after transplantation, non-risk adjusted graft and patient survival of patients with HCV + ALD are comparable to
those of patients with HCV cirrhosis or ALD cirrhosis alone. In the short and medium term HCV recurrence after transplant in patients with
HCV + ALD cirrhosis does not seem more aggressive than that in patients with HCV cirrhosis alone. A relapse in alcohol consumption in
patients with HCV + ALD cirrhosis does not have a major impact on graft survival. The evidence shows that, as is currently practiced,
HCV + ALD as an appropriate indication for liver transplantation. However, these data are based on retrospective analyses with relatively
short follow-up so the conclusions must be treated with caution. |
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| ISSN: | 2090-0007 2090-0015 |