Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation

Abstract Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hydrolases (Fphs), which regulate aspects of virulence and lipid metabolism. However, due to...

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Main Authors: Tulsi Upadhyay, Emily C. Woods, Stephen Dela Ahator, Kjersti Julin, Franco F. Faucher, Md Jalal Uddin, Marijn J. Hollander, Nichole J. Pedowitz, Daniel Abegg, Isabella Hammond, Ifeanyichukwu E. Eke, Sijie Wang, Shiyu Chen, John M. Bennett, Jeyun Jo, Christian S. Lentz, Alexander Adibekian, Matthias Fellner, Matthew Bogyo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60367-3
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https://doi.org/10.1038/s41467-025-60367-3

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