Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature
A 69-year-old woman on nonsteroidal anti-inflammatory drugs (NSAIDs) was admitted to a university hospital with abdominal pain, profound anemia and melena stools. Duodenal ulceration and subsequent healing were documented. Colonoscopy revealed haustral ulceration and NSAID-induced colonic diaphragm...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/306498 |
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| _version_ | 1832556193618329600 |
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| author | Robert M Penner C Noel Williams |
| author_facet | Robert M Penner C Noel Williams |
| author_sort | Robert M Penner |
| collection | DOAJ |
| description | A 69-year-old woman on nonsteroidal anti-inflammatory drugs (NSAIDs) was admitted to a university hospital with abdominal pain, profound anemia and melena stools. Duodenal ulceration and subsequent healing were documented. Colonoscopy revealed haustral ulceration and NSAID-induced colonic diaphragm disease. Discontinuation of NSAID therapy did not result in endoscopic change, but a 20-week course of prednisone was followed by complete resolution. This is the first case describing prednisone monotherapy for such strictures, and only the second in which endoscopic resolution has been documented. With further supporting experience, prednisone may be considered in addition to NSAID discontinuation for patients with this rare but serious complication. |
| format | Article |
| id | doaj-art-7136d4e3f9d842dabbd5b2390dcd0ea7 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-7136d4e3f9d842dabbd5b2390dcd0ea72025-02-03T05:46:07ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-0117849750010.1155/2003/306498Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the LiteratureRobert M Penner0C Noel Williams1Department of Medicine, Division of Gastroenterology University of Alberta, Edmonton, Alberta, CanadaDepartment of Medicine, Division of Gastroenterology University of Alberta, Edmonton, Alberta, CanadaA 69-year-old woman on nonsteroidal anti-inflammatory drugs (NSAIDs) was admitted to a university hospital with abdominal pain, profound anemia and melena stools. Duodenal ulceration and subsequent healing were documented. Colonoscopy revealed haustral ulceration and NSAID-induced colonic diaphragm disease. Discontinuation of NSAID therapy did not result in endoscopic change, but a 20-week course of prednisone was followed by complete resolution. This is the first case describing prednisone monotherapy for such strictures, and only the second in which endoscopic resolution has been documented. With further supporting experience, prednisone may be considered in addition to NSAID discontinuation for patients with this rare but serious complication.http://dx.doi.org/10.1155/2003/306498 |
| spellingShingle | Robert M Penner C Noel Williams Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature Canadian Journal of Gastroenterology |
| title | Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature |
| title_full | Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature |
| title_fullStr | Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature |
| title_full_unstemmed | Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature |
| title_short | Resolution of Multiple Severe Nonsteroidal Anti-Inflammatory Drug-Induced Colonic Strictures with Prednisone Therapy: A Case Report and Review of the Literature |
| title_sort | resolution of multiple severe nonsteroidal anti inflammatory drug induced colonic strictures with prednisone therapy a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2003/306498 |
| work_keys_str_mv | AT robertmpenner resolutionofmultipleseverenonsteroidalantiinflammatorydruginducedcolonicstrictureswithprednisonetherapyacasereportandreviewoftheliterature AT cnoelwilliams resolutionofmultipleseverenonsteroidalantiinflammatorydruginducedcolonicstrictureswithprednisonetherapyacasereportandreviewoftheliterature |