Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study
Abstract This retrospective study evaluated the use of laminin γ2 monomer (LG2m) as a predictive biomarker for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Serum LG2m levels were measured in two cohorts of patients: cohort 1 comprised 56 patients with ch...
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Nature Portfolio
2024-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-77068-4 |
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| author | Kouki Nio Tetsuro Shimakami Takeshi Terashima Masahiro Yanagi Tadashi Toyama Naohiko Koshikawa Masatoshi Nakagawa Eisaku Yoshida Toru Yoshimura Motoharu Seiki Masao Honda Taro Yamashita |
| author_facet | Kouki Nio Tetsuro Shimakami Takeshi Terashima Masahiro Yanagi Tadashi Toyama Naohiko Koshikawa Masatoshi Nakagawa Eisaku Yoshida Toru Yoshimura Motoharu Seiki Masao Honda Taro Yamashita |
| author_sort | Kouki Nio |
| collection | DOAJ |
| description | Abstract This retrospective study evaluated the use of laminin γ2 monomer (LG2m) as a predictive biomarker for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Serum LG2m levels were measured in two cohorts of patients: cohort 1 comprised 56 patients with chronic liver disease for assessing LG2m stability, whereas cohort 2 included 89 patients with chronic HBV infection who did not have HCC for evaluating the usefulness of LG2m measurement in HCC prediction. LG2m was highly stable in cryopreserved serum, and an increased LG2m level was significantly associated with a higher risk of HCC in chronically HBV-infected patients (P = 0.012). Multivariable Cox regression analysis revealed that high LG2m was an independent significant risk factor for HCC (hazard ratio, 7.16; 95% confidence interval, 1.31–39.2; P = 0.023). These findings suggest that LG2m may serve as a useful biomarker for the prediction of future HCC in patients with chronic HBV infection. |
| format | Article |
| id | doaj-art-712d892e511d457d80aff9fe7ec661ce |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-712d892e511d457d80aff9fe7ec661ce2025-08-20T02:11:29ZengNature PortfolioScientific Reports2045-23222024-10-011411610.1038/s41598-024-77068-4Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort studyKouki Nio0Tetsuro Shimakami1Takeshi Terashima2Masahiro Yanagi3Tadashi Toyama4Naohiko Koshikawa5Masatoshi Nakagawa6Eisaku Yoshida7Toru Yoshimura8Motoharu Seiki9Masao Honda10Taro Yamashita11Department of Gastroenterology, Kanazawa University HospitalDepartment of Gastroenterology, Kanazawa University HospitalDepartment of Gastroenterology, Kanazawa University HospitalDepartment of Gastroenterology, Kanazawa University HospitalInnovative Clinical Research Center, Kanazawa University HospitalDepartment of Life Science and Technology, Tokyo Institute of TechnologyDiagnostics Division, Abbott Japan LLCDiagnostics Division, Abbott Japan LLCDiagnostics Division, Abbott Japan LLCDepartment of Gastroenterology, Kanazawa University HospitalDepartment of Gastroenterology, Kanazawa University HospitalDepartment of Gastroenterology, Kanazawa University HospitalAbstract This retrospective study evaluated the use of laminin γ2 monomer (LG2m) as a predictive biomarker for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Serum LG2m levels were measured in two cohorts of patients: cohort 1 comprised 56 patients with chronic liver disease for assessing LG2m stability, whereas cohort 2 included 89 patients with chronic HBV infection who did not have HCC for evaluating the usefulness of LG2m measurement in HCC prediction. LG2m was highly stable in cryopreserved serum, and an increased LG2m level was significantly associated with a higher risk of HCC in chronically HBV-infected patients (P = 0.012). Multivariable Cox regression analysis revealed that high LG2m was an independent significant risk factor for HCC (hazard ratio, 7.16; 95% confidence interval, 1.31–39.2; P = 0.023). These findings suggest that LG2m may serve as a useful biomarker for the prediction of future HCC in patients with chronic HBV infection.https://doi.org/10.1038/s41598-024-77068-4 |
| spellingShingle | Kouki Nio Tetsuro Shimakami Takeshi Terashima Masahiro Yanagi Tadashi Toyama Naohiko Koshikawa Masatoshi Nakagawa Eisaku Yoshida Toru Yoshimura Motoharu Seiki Masao Honda Taro Yamashita Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study Scientific Reports |
| title | Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study |
| title_full | Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study |
| title_fullStr | Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study |
| title_full_unstemmed | Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study |
| title_short | Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study |
| title_sort | serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis b virus infection a retrospective cohort study |
| url | https://doi.org/10.1038/s41598-024-77068-4 |
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