A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems
Phytochemical study of Rourea oligophlebia stems led to the isolation of a new 2-pyrrolidone alkaloid (R,S)-N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1), together with 14 known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/6659106 |
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| author | Thuc Ngoc Dinh Mai Vu Thi Ha Luong Ngo Xuan Huan Trinh Thi Huong Nguyen Thi Mai Nguyen Thi Ngoc Giap Tran Huu Oanh Vu Thi Kim Thanh Le Nguyen |
| author_facet | Thuc Ngoc Dinh Mai Vu Thi Ha Luong Ngo Xuan Huan Trinh Thi Huong Nguyen Thi Mai Nguyen Thi Ngoc Giap Tran Huu Oanh Vu Thi Kim Thanh Le Nguyen |
| author_sort | Thuc Ngoc Dinh |
| collection | DOAJ |
| description | Phytochemical study of Rourea oligophlebia stems led to the isolation of a new 2-pyrrolidone alkaloid (R,S)-N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1), together with 14 known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15). Several isolated compounds were evaluated for cytotoxicity and antimicrobial activity. Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 8–10 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively. |
| format | Article |
| id | doaj-art-71252bedfd2043a9af8297610ed2be8c |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-71252bedfd2043a9af8297610ed2be8c2025-02-03T05:43:46ZengWileyJournal of Chemistry2090-90632090-90712021-01-01202110.1155/2021/66591066659106A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia StemsThuc Ngoc Dinh0Mai Vu Thi Ha1Luong Ngo Xuan2Huan Trinh Thi3Huong Nguyen Thi4Mai Nguyen Thi Ngoc5Giap Tran Huu6Oanh Vu Thi Kim7Thanh Le Nguyen8Department of Science and Technology Management, Hong Duc University, Thanh Hoa, VietnamDepartment of Science and Technology Management, Hong Duc University, Thanh Hoa, VietnamFaculty of Natural Sciences, Hong Duc University, Thanh Hoa, VietnamFaculty of Natural Sciences, Hong Duc University, Thanh Hoa, VietnamFaculty of Natural Sciences, Hong Duc University, Thanh Hoa, VietnamFaculty of Natural Sciences, Hong Duc University, Thanh Hoa, VietnamInstitute of Marine Biochemistry (IMBC) and Graduate University of Science and Technology (GUST), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamInstitute of Marine Biochemistry (IMBC) and Graduate University of Science and Technology (GUST), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamInstitute of Marine Biochemistry (IMBC) and Graduate University of Science and Technology (GUST), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, VietnamPhytochemical study of Rourea oligophlebia stems led to the isolation of a new 2-pyrrolidone alkaloid (R,S)-N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1), together with 14 known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15). Several isolated compounds were evaluated for cytotoxicity and antimicrobial activity. Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 8–10 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively.http://dx.doi.org/10.1155/2021/6659106 |
| spellingShingle | Thuc Ngoc Dinh Mai Vu Thi Ha Luong Ngo Xuan Huan Trinh Thi Huong Nguyen Thi Mai Nguyen Thi Ngoc Giap Tran Huu Oanh Vu Thi Kim Thanh Le Nguyen A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems Journal of Chemistry |
| title | A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems |
| title_full | A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems |
| title_fullStr | A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems |
| title_full_unstemmed | A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems |
| title_short | A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems |
| title_sort | new pyrrolidone alkaloid and other constituents from rourea oligophlebia stems |
| url | http://dx.doi.org/10.1155/2021/6659106 |
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