A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?
Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed hi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/8856649 |
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| author | Jiankun Tong Jean Luo Pierre F. Saldinger William H. Rodgers |
| author_facet | Jiankun Tong Jean Luo Pierre F. Saldinger William H. Rodgers |
| author_sort | Jiankun Tong |
| collection | DOAJ |
| description | Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature. |
| format | Article |
| id | doaj-art-7124b3c402a046d4823d16209093642d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-7124b3c402a046d4823d16209093642d2025-02-03T00:58:55ZengWileyCase Reports in Hematology2090-65602090-65792021-01-01202110.1155/2021/88566498856649A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?Jiankun Tong0Jean Luo1Pierre F. Saldinger2William H. Rodgers3Department of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USADepartment of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USADepartment of Surgery, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USADepartment of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USAHistiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.http://dx.doi.org/10.1155/2021/8856649 |
| spellingShingle | Jiankun Tong Jean Luo Pierre F. Saldinger William H. Rodgers A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? Case Reports in Hematology |
| title | A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? |
| title_full | A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? |
| title_fullStr | A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? |
| title_full_unstemmed | A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? |
| title_short | A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity? |
| title_sort | rare case of histiocytic sarcoma secondary to gastrointestinal stromal tumor in the stomach transdifferentiation or synchronicity |
| url | http://dx.doi.org/10.1155/2021/8856649 |
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