Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent
Recent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia...
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| Language: | English |
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Wiley
2013-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/820849 |
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| author | Xin Gu Tao Huang Ding Xu Liujian Duan Yang Jiao Jian Kang S. Lilly Zheng Jianfeng Xu Jielin Sun Jun Qi |
| author_facet | Xin Gu Tao Huang Ding Xu Liujian Duan Yang Jiao Jian Kang S. Lilly Zheng Jianfeng Xu Jielin Sun Jun Qi |
| author_sort | Xin Gu |
| collection | DOAJ |
| description | Recent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia (BPH). The current study included 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. All BPH patients were treated with α-adrenergic blockers and 5α-reductase inhibitors for at least 9 months. Associations between rs2252004 and BPH risk/aggressiveness were tested using logistic regression. Associations between rs2252004 and clinical parameters including International Prostate Symptom Score (IPSS), total prostate volume (TPV), total PSA (tPSA), and free PSA (fPSA) were evaluated by linear regression. Allele “A” in rs2252004 was significantly associated with increased risk for aggressiveness of BPH in a Chinese population (OR = 1.42, 95% CI: 1.04–1.96, P=0.03). Patients with the genotype “A/A” (homozygous minor allele) had an increase of IPSS and TPV after treatment (P=0.045 and 0.024, resp.). No association was observed between rs2252004, BPH risk, and baseline clinicopathological traits (All P>0.05). Our study is the first to show that rs2252004 at 10q26 was associated with BPH aggressiveness and efficacy of BPH treatment. |
| format | Article |
| id | doaj-art-711de1c223fa45f0a111c039d32e3778 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Biochemistry Research International |
| spelling | doaj-art-711de1c223fa45f0a111c039d32e37782025-02-03T05:54:29ZengWileyBiochemistry Research International2090-22472090-22552013-01-01201310.1155/2013/820849820849Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese DescentXin Gu0Tao Huang1Ding Xu2Liujian Duan3Yang Jiao4Jian Kang5S. Lilly Zheng6Jianfeng Xu7Jielin Sun8Jun Qi9Department of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaDepartment of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaDepartment of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaDepartment of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaDepartment of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaDepartment of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaDepartment of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaCenter for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USACenter for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USADepartment of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, ChinaRecent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia (BPH). The current study included 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. All BPH patients were treated with α-adrenergic blockers and 5α-reductase inhibitors for at least 9 months. Associations between rs2252004 and BPH risk/aggressiveness were tested using logistic regression. Associations between rs2252004 and clinical parameters including International Prostate Symptom Score (IPSS), total prostate volume (TPV), total PSA (tPSA), and free PSA (fPSA) were evaluated by linear regression. Allele “A” in rs2252004 was significantly associated with increased risk for aggressiveness of BPH in a Chinese population (OR = 1.42, 95% CI: 1.04–1.96, P=0.03). Patients with the genotype “A/A” (homozygous minor allele) had an increase of IPSS and TPV after treatment (P=0.045 and 0.024, resp.). No association was observed between rs2252004, BPH risk, and baseline clinicopathological traits (All P>0.05). Our study is the first to show that rs2252004 at 10q26 was associated with BPH aggressiveness and efficacy of BPH treatment.http://dx.doi.org/10.1155/2013/820849 |
| spellingShingle | Xin Gu Tao Huang Ding Xu Liujian Duan Yang Jiao Jian Kang S. Lilly Zheng Jianfeng Xu Jielin Sun Jun Qi Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent Biochemistry Research International |
| title | Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent |
| title_full | Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent |
| title_fullStr | Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent |
| title_full_unstemmed | Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent |
| title_short | Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent |
| title_sort | association of a common variant at 10q26 and benign prostatic hyperplasia aggressiveness in han chinese descent |
| url | http://dx.doi.org/10.1155/2013/820849 |
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