Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in several organs including endocrine glands. Among endocrine irAEs, thyroid and pituitary irAEs are frequently observed, followed by primary adrenal insufficiency, insulin-dependent diabetes mellitus, and hypoparath...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Japan Endocrine Society
2024-01-01
|
| Series: | Endocrine Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/1/71_EJ23-0524/_html/-char/en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591707687878656 |
|---|---|
| author | Tomoko Kobayashi Shintaro Iwama Hiroshi Arima |
| author_facet | Tomoko Kobayashi Shintaro Iwama Hiroshi Arima |
| author_sort | Tomoko Kobayashi |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in several organs including endocrine glands. Among endocrine irAEs, thyroid and pituitary irAEs are frequently observed, followed by primary adrenal insufficiency, insulin-dependent diabetes mellitus, and hypoparathyroidism. These conditions could lead to life-threatening consequences, such as adrenal crisis and diabetic ketoacidosis. On the other hand, several types of irAEs including thyroid and pituitary irAEs are reported to be associated with better overall survival. Therefore, it is important to understand and manage endocrine irAEs, which differ depending on the ICI regimen used. In this review, we describe the clinical features, potential biomarkers, management strategies, and possible mechanisms of thyroid and pituitary irAEs. |
| format | Article |
| id | doaj-art-711cb5a3651140c6a4e328d032deb79f |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-711cb5a3651140c6a4e328d032deb79f2025-01-22T06:31:09ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-01-01711232910.1507/endocrj.EJ23-0524endocrjClinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse eventsTomoko Kobayashi0Shintaro Iwama1Hiroshi Arima2Department of Endocrinology and Diabetes, Nagoya University Hospital, Nagoya 466-8550, JapanDepartment of Endocrinology and Diabetes, Nagoya University Hospital, Nagoya 466-8550, JapanDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, JapanImmune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in several organs including endocrine glands. Among endocrine irAEs, thyroid and pituitary irAEs are frequently observed, followed by primary adrenal insufficiency, insulin-dependent diabetes mellitus, and hypoparathyroidism. These conditions could lead to life-threatening consequences, such as adrenal crisis and diabetic ketoacidosis. On the other hand, several types of irAEs including thyroid and pituitary irAEs are reported to be associated with better overall survival. Therefore, it is important to understand and manage endocrine irAEs, which differ depending on the ICI regimen used. In this review, we describe the clinical features, potential biomarkers, management strategies, and possible mechanisms of thyroid and pituitary irAEs.https://www.jstage.jst.go.jp/article/endocrj/71/1/71_EJ23-0524/_html/-char/enthyroidpituitaryimmune checkpoint inhibitors (icis)immune-related adverse events (iraes)biomarkers |
| spellingShingle | Tomoko Kobayashi Shintaro Iwama Hiroshi Arima Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events Endocrine Journal thyroid pituitary immune checkpoint inhibitors (icis) immune-related adverse events (iraes) biomarkers |
| title | Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events |
| title_full | Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events |
| title_fullStr | Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events |
| title_full_unstemmed | Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events |
| title_short | Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events |
| title_sort | clinical characteristics and potential biomarkers of thyroid and pituitary immune related adverse events |
| topic | thyroid pituitary immune checkpoint inhibitors (icis) immune-related adverse events (iraes) biomarkers |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/1/71_EJ23-0524/_html/-char/en |
| work_keys_str_mv | AT tomokokobayashi clinicalcharacteristicsandpotentialbiomarkersofthyroidandpituitaryimmunerelatedadverseevents AT shintaroiwama clinicalcharacteristicsandpotentialbiomarkersofthyroidandpituitaryimmunerelatedadverseevents AT hiroshiarima clinicalcharacteristicsandpotentialbiomarkersofthyroidandpituitaryimmunerelatedadverseevents |