Coronavirus Host Genomics Study: South Africa (COVIGen-SA)
Host genetic factors are known to modify the susceptibility, severity, and outcomes of COVID-19 and vary across populations. However, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa’s response to the pandemic...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Global Health, Epidemiology and Genomics |
| Online Access: | http://dx.doi.org/10.1155/2022/7405349 |
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| author | Andrew K. May Heather Seymour Harriet Etheredge Heather Maher Marta C. Nunes Shabir A. Madhi Simiso M. Sokhela W. D. Francois Venter Neil Martinson Firdaus Nabeemeeah Cheryl Cohen Jocelyn Moyes Sibongile Walaza Stefano Tempia Jackie Kleynhans Anne von Gottberg Jeremy Nel Halima Dawood Ebrahim Variava Stephen Tollman Kathleen Kahn Kobus Herbst Emily B. Wong Caroline T. Tiemessen Alex van Blydenstein Lyle Murray Michelle Venter June Fabian Michéle Ramsay |
| author_facet | Andrew K. May Heather Seymour Harriet Etheredge Heather Maher Marta C. Nunes Shabir A. Madhi Simiso M. Sokhela W. D. Francois Venter Neil Martinson Firdaus Nabeemeeah Cheryl Cohen Jocelyn Moyes Sibongile Walaza Stefano Tempia Jackie Kleynhans Anne von Gottberg Jeremy Nel Halima Dawood Ebrahim Variava Stephen Tollman Kathleen Kahn Kobus Herbst Emily B. Wong Caroline T. Tiemessen Alex van Blydenstein Lyle Murray Michelle Venter June Fabian Michéle Ramsay |
| author_sort | Andrew K. May |
| collection | DOAJ |
| description | Host genetic factors are known to modify the susceptibility, severity, and outcomes of COVID-19 and vary across populations. However, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa’s response to the pandemic. We describe the development of a research resource for coronavirus host genomics studies in South Africa known as COVIGen-SA—a multicollaborator strategic partnership designed to provide harmonised demographic, clinical, and genetic information specific to Black South Africans with COVID-19. Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. Through this resource, we aim to provide insights into host genetic factors relevant to African-ancestry populations, using both genome-wide association testing and targeted sequencing of important genomic loci. This project will promote and enhance partnerships, build skills, and develop resources needed to address the COVID-19 burden and associated risk factors in South African communities. |
| format | Article |
| id | doaj-art-7113f2e5f36d4849ab74e83e531752ff |
| institution | Kabale University |
| issn | 2054-4200 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Global Health, Epidemiology and Genomics |
| spelling | doaj-art-7113f2e5f36d4849ab74e83e531752ff2025-02-03T01:21:03ZengWileyGlobal Health, Epidemiology and Genomics2054-42002022-01-01202210.1155/2022/7405349Coronavirus Host Genomics Study: South Africa (COVIGen-SA)Andrew K. May0Heather Seymour1Harriet Etheredge2Heather Maher3Marta C. Nunes4Shabir A. Madhi5Simiso M. Sokhela6W. D. Francois Venter7Neil Martinson8Firdaus Nabeemeeah9Cheryl Cohen10Jocelyn Moyes11Sibongile Walaza12Stefano Tempia13Jackie Kleynhans14Anne von Gottberg15Jeremy Nel16Halima Dawood17Ebrahim Variava18Stephen Tollman19Kathleen Kahn20Kobus Herbst21Emily B. Wong22Caroline T. Tiemessen23Alex van Blydenstein24Lyle Murray25Michelle Venter26June Fabian27Michéle Ramsay28Sydney Brenner Institute for Molecular Bioscience (SBIMB)Sydney Brenner Institute for Molecular Bioscience (SBIMB)Wits Donald Gordon Medical CentreWits Donald Gordon Medical CentreSouth African Medical Research CouncilSouth African Medical Research CouncilEzintsha, Wits Health ConsortiumEzintsha, Wits Health ConsortiumCentre for Respiratory Diseases and MeningitisPerinatal HIV Research UnitDivision of Infectious DiseasesDivision of Infectious DiseasesDivision of Infectious DiseasesDivision of Infectious DiseasesDivision of Infectious DiseasesDivision of Infectious DiseasesDepartment of MedicineCaprisa University of KwaZulu-NatalKlerksdorp-Tshepong Hospital Complex, Klerksdorp, and Department of MedicineMRC/Wits Rural Public Health and Health Transitions Unit (Agincourt)MRC/Wits Rural Public Health and Health Transitions Unit (Agincourt)Africa Health Research InstituteAfrica Health Research InstituteCentre for HIV and STIsDivision of PulmonologyDepartment of MedicineDepartment of MedicineWits Donald Gordon Medical CentreSydney Brenner Institute for Molecular Bioscience (SBIMB)Host genetic factors are known to modify the susceptibility, severity, and outcomes of COVID-19 and vary across populations. However, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa’s response to the pandemic. We describe the development of a research resource for coronavirus host genomics studies in South Africa known as COVIGen-SA—a multicollaborator strategic partnership designed to provide harmonised demographic, clinical, and genetic information specific to Black South Africans with COVID-19. Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. Through this resource, we aim to provide insights into host genetic factors relevant to African-ancestry populations, using both genome-wide association testing and targeted sequencing of important genomic loci. This project will promote and enhance partnerships, build skills, and develop resources needed to address the COVID-19 burden and associated risk factors in South African communities.http://dx.doi.org/10.1155/2022/7405349 |
| spellingShingle | Andrew K. May Heather Seymour Harriet Etheredge Heather Maher Marta C. Nunes Shabir A. Madhi Simiso M. Sokhela W. D. Francois Venter Neil Martinson Firdaus Nabeemeeah Cheryl Cohen Jocelyn Moyes Sibongile Walaza Stefano Tempia Jackie Kleynhans Anne von Gottberg Jeremy Nel Halima Dawood Ebrahim Variava Stephen Tollman Kathleen Kahn Kobus Herbst Emily B. Wong Caroline T. Tiemessen Alex van Blydenstein Lyle Murray Michelle Venter June Fabian Michéle Ramsay Coronavirus Host Genomics Study: South Africa (COVIGen-SA) Global Health, Epidemiology and Genomics |
| title | Coronavirus Host Genomics Study: South Africa (COVIGen-SA) |
| title_full | Coronavirus Host Genomics Study: South Africa (COVIGen-SA) |
| title_fullStr | Coronavirus Host Genomics Study: South Africa (COVIGen-SA) |
| title_full_unstemmed | Coronavirus Host Genomics Study: South Africa (COVIGen-SA) |
| title_short | Coronavirus Host Genomics Study: South Africa (COVIGen-SA) |
| title_sort | coronavirus host genomics study south africa covigen sa |
| url | http://dx.doi.org/10.1155/2022/7405349 |
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