DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology
In 2001, two enzyme-encoding genes were recognized in the fruit fly <i>Drosophila melanogaster</i>. The genetic material, labeled <i>Dicer-1</i> and <i>Dicer-2</i>, encodes ribonuclease-type enzymes with slightly diverse target substrates. The human orthologue is...
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| author | Consolato M. Sergi Fabrizio Minervini |
| author_facet | Consolato M. Sergi Fabrizio Minervini |
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| description | In 2001, two enzyme-encoding genes were recognized in the fruit fly <i>Drosophila melanogaster</i>. The genetic material, labeled <i>Dicer-1</i> and <i>Dicer-2</i>, encodes ribonuclease-type enzymes with slightly diverse target substrates. The human orthologue is <i>DICER1</i>. It is a gene, which has been positioned on chromosome 14q32.13. It contains 27 exons, which are linking the two enzyme domains. <i>DICER1</i> is found in all organ systems. It has been proved that it is paramount in human development. The protein determined by <i>DICER1</i> is a ribonuclease (RNase). This RNase belongs to the RNase III superfamily, formally known as ’endoribonuclease’. It has been determined that the function of RNase III proteins is set to identify and degrade double-stranded molecules of RNA. <i>DICER1</i> is a vital “housekeeping” gene. The multi-domain enzyme is key for small RNA processing. This enzyme functions in numerous pathways, including RNA interference paths, DNA damage renovation, and response to viruses. At the protein level, DICER is also involved in several human diseases, of which the pleuro-pulmonary blastoma is probably the most egregious entity. Numerous studies have determined the full range of DICER1 functions and the corresponding relationship to tumorigenic and non-neoplastic diseases. In fact, genetic mutations (somatic and germline) have been detected in <i>DICER1</i> and are genetically associated with at least two clinical syndromes: DICER1 syndrome and GLOW syndrome. The ubiquity of this enzyme in the human body makes it an exquisite target for nanotechnology-supported therapies and repurposing drug approaches. |
| format | Article |
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| institution | Kabale University |
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| spelling | doaj-art-710c2fe8098847299ee582382d29e54f2025-01-24T13:23:37ZengMDPI AGBiology2079-77372025-01-011419310.3390/biology14010093DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth PathologyConsolato M. Sergi0Fabrizio Minervini1Division of Anatomic Pathology, Children’s Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, CanadaDivision of Thoracic Surgery, Cantonal Hospital Lucerne, 6000 Lucerne, SwitzerlandIn 2001, two enzyme-encoding genes were recognized in the fruit fly <i>Drosophila melanogaster</i>. The genetic material, labeled <i>Dicer-1</i> and <i>Dicer-2</i>, encodes ribonuclease-type enzymes with slightly diverse target substrates. The human orthologue is <i>DICER1</i>. It is a gene, which has been positioned on chromosome 14q32.13. It contains 27 exons, which are linking the two enzyme domains. <i>DICER1</i> is found in all organ systems. It has been proved that it is paramount in human development. The protein determined by <i>DICER1</i> is a ribonuclease (RNase). This RNase belongs to the RNase III superfamily, formally known as ’endoribonuclease’. It has been determined that the function of RNase III proteins is set to identify and degrade double-stranded molecules of RNA. <i>DICER1</i> is a vital “housekeeping” gene. The multi-domain enzyme is key for small RNA processing. This enzyme functions in numerous pathways, including RNA interference paths, DNA damage renovation, and response to viruses. At the protein level, DICER is also involved in several human diseases, of which the pleuro-pulmonary blastoma is probably the most egregious entity. Numerous studies have determined the full range of DICER1 functions and the corresponding relationship to tumorigenic and non-neoplastic diseases. In fact, genetic mutations (somatic and germline) have been detected in <i>DICER1</i> and are genetically associated with at least two clinical syndromes: DICER1 syndrome and GLOW syndrome. The ubiquity of this enzyme in the human body makes it an exquisite target for nanotechnology-supported therapies and repurposing drug approaches.https://www.mdpi.com/2079-7737/14/1/93DICER1oncogenebiologymolecular genetics |
| spellingShingle | Consolato M. Sergi Fabrizio Minervini DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology Biology DICER1 oncogene biology molecular genetics |
| title | DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology |
| title_full | DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology |
| title_fullStr | DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology |
| title_full_unstemmed | DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology |
| title_short | DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology |
| title_sort | dicer1 the argonaute endonuclease family member and its role in pediatric and youth pathology |
| topic | DICER1 oncogene biology molecular genetics |
| url | https://www.mdpi.com/2079-7737/14/1/93 |
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